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The hydrogen peroxide induced enhancement of DNA cleavage in the ambient light photolysis of CpFe(CO)2Ph: a potential strategy for targeting cancer cells

, : The hydrogen peroxide induced enhancement of DNA cleavage in the ambient light photolysis of CpFe(CO)2Ph: a potential strategy for targeting cancer cells. Bioorganic & Medicinal Chemistry Letters 15(20): 4585-4588

DNA strand scission is produced by the ambient light photolysis of CpFe(CO)(2)Ph and H2O2, a result that shows potential as a means of targeting tumors, due to the high levels of hydrogen peroxide in cancer cells. This cleavage process is dependent on the concentration of both CpFe(CO)(2)Ph and H2O2, and preliminary experiments implicate both carbon-centered radicals and reactive oxygen species. (c) 2005 Elsevier Ltd. All rights reserved.


PMID: 16115764

DOI: 10.1016/j.bmcl.2005.06.102

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