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The hyperbilirubinemic Gunn rat is resistant to the pressor effects of angiotensin II


, : The hyperbilirubinemic Gunn rat is resistant to the pressor effects of angiotensin II. American Journal of Physiology. Renal Physiology 288(3): F552-F558

The hyperbilirubinemic Gunn rat is resistant to the pressor effects of angiotensin II. Am J Physiol Renal Physiol 288: F552-F558, 2005. First published November 9, 2004; doi:10.1152/ajprenal. 00278.2004.-ANG II induces vasoconstriction, at least in part, by stimulating NADPH oxidase and generating reactive oxygen species. ANG II also induces heme oxygenase activity, and bilirubin, a product of such activity, possesses antioxidant properties. We hypothesized that bilirubin, because of its antioxidant properties, may reduce the pressor and prooxidant effects of ANG II. Our in vivo studies used the hyperbilirubinemic Gunn rat which is deficient in the enzyme uridine diphosphate glucuronosyl transferase, the latter enabling the excretion of bilirubin into bile. ANG II (0.5 mg.kg-1.day-1) or saline vehicle was administered by osmotic minipump to control and Gunn rats for 4 wk. The rise in systolic blood pressure induced by ANG II, as observed in control rats, was markedly reduced in Gunn rats, the latter -50 % less at 3 and 4 wk after the initiation of ANG II infusion. The chronic administration of ANG II also impaired endothelium-dependent relaxation responses in control rats but not in Gunn rats. As assessed by the tetrahydrobiopterin/dihydrobiopterin ratio, ANG II induced oxidative stress in the aorta in control rats but not in Gunn rats. Heightened generation of superoxide anion in aortic rings in ANG II-infused rats and by vascular smooth muscle cells exposed to ANG II was normalized by bilirubin in vitro. We conclude that the pressor and prooxidant effects of ANG II are attenuated in the hyperbilirubinemic Gunn rat, an effect which, we speculate, may reflect, at least in part, the scavenging of superoxide anion by bilirubin.

US$19.90

PMID: 15536166

DOI: 10.1152/ajprenal.00278.2004


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Han JunHua; Feng MeiYuan; Wang GuoDong; Yang YueXin, 2006: Analysis of phytosterols content in cereals and legumes. The phytosterol contents of cereals and legumes commonly consumed in China were analysed, as well as the phytosterol intake of the Chinese people. Twenty-five cereals and 16 legumes were selected, and data from a 2002 national survey on Chinese nu...

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Becker, A.; Peters, B.; Schroeder, H.; Mann, T.; Huether, G.; Grecksch, G., 2003: Ketamine-induced changes in rat behaviour: A possible animal model of schizophrenia. It was investigated whether subchronic application of 30 mg/kg ketamine (Ket) induces reliable changes in behaviour and parameters of dopaminergic, glutamatergic, and serotonergic neurotransmissions, which might be the basis of an animal model in...

Agosin, M.; Ilivicky, J.; Litvak, S., 1967: The induction of NAD kinase by DDT in Triatoma infestans. The NAD kinase (EC 2.7.1.23) from Triatoma infestans has been purified and a specific antiserum against it prepared. Immuno-chemical techniques have shown that the increase in the levels of NAD kinase in nymphs of T. infestans is accompanied by an...

Warren L.R., 1982: Effect of incentive on cerebral blood flow during mental arithmetic. Bulletin Of The Psychonomic Society: 151

Guan, L-zheng.; Sun, Y-ping.; Xi, Q-yun.; Wang, J-lan.; Zhou, J-yun.; Shu, G.; Jiang, Q-yan.; Zhang, Y-liang., 2014: β-Glucanase specific expression in the parotid gland of transgenic mice. The feasibility of using the pig parotid secretory protein promoter to drive the β-glucanase transgene expression in mouse parotid glands was examined in this study. The parotid gland-specific vector expressing β-glucanase gene (GLU, from Paenib...

Shirai, Y., 1988: Ecological studies on phytophagous lady beetles, Henosepilachna vingtioctomaculata complex, (Coleoptera: Coccinellidae) in the Ina area, Nagano Prefecture 3. Population dynamics and life cycle characteristics of H. yasutomii feeding on deadly nightshade, Scopolia japonica (Solanaceae). Japanese Journal of Ecology, 382: 111-119