geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The identification of a functional interaction between PKC and topoisomerase II


, : The identification of a functional interaction between PKC and topoisomerase II. Febs Letters 580(1): 51-57

Topoisomerase II plays an essential role in the segregation of chromosomes during cell division. It is also a major component of the nuclear matrix. Proteins that interact with and regulate this essential enzyme are of great interest. To investigate the role of proteins interacting with the N-terminal domain of the Saccharomyces cerevisiae topoisomerase II, we used a yeast two-hybrid protein interaction screen. We identified an interaction between the catalytic domain of the yeast protein kinase 2 enzyme (Pkc1) and the N-terminal domain of the,S. cerevisiae topoisomerase II. The S. cerevisiae Pkc1 is the homologue of the mammalian calcium dependent PKC. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier, B.V. All rights reserved.

US$19.90

PMID: 16364307

DOI: 10.1016/j.febslet.2005.11.075


Other references

Snajdr M., 1979: 2 trinucleid trilobites with repair of traumatic injury. Exoskeletons of 2 trinucleid trilobites [Marrolithus senftenbergi and Deanaspis goldfussi] with repaired injuries were described from the Ordovician, Bohemia. In both cases the injuries were caused by unknown predators.

Schiller, J.H., 2001: Novel therapies in lung cancer management. An update on the role of topotecan. Oncology 61 Suppl 1: 1-2

Anonymous, 1967: Are isometric exercises safe?. London Clinic Medical Journal 8(2): 11-14

Hodgson, A.L.; Krywult, J.; Corner, L.A.; Rothel, J.S.; Radford, A.J., 1992: Rational attenuation of Corynebacterium pseudotuberculosis: potential cheesy gland vaccine and live delivery vehicle. The phospholipase D (PLD) gene (pld) has been deleted from the Corynebacterium pseudotuberculosis chromosome by using site-specific mutagenesis. Sheep infection trials indicate that the PLD-negative C. pseudotuberculosis strain (Toxminus) is incap...

Grubb, T.C., 1969: Narcolepsy and highway accidents. JAMA 209(11): 1720-1720

D.C.stro Fettuccia, D.; Simoes Lopes, P.C.sar, 2004: Morfologia da coluna vertebral do botocinza, Sotalia guianensis (Cetacea, Delphinidae). We present a description of the backbone of the marine tucuxi (Sotalia guianensis) vertebrae (n=34), including the variations in the vertebral formula (n=32) (UFSC-Universidade Federal de Santa Catarina): Ce7, T12, L10-12, Ca23-25 = 52-56. Species...

Pavlygina, R.A., 1978: Role of the inhibitory process in the closing of a simple form of temporary connection. Summational reflex in cats, occurring in the structures of the cerebral cortex, was studied as a manifestation of the simple form of integrative activity of the brain. Subthreshold stimulation with electric current of the motor cortex surface in t...

Walker J.M.; Moises H.C.; Freiderich M.W., 1984: Opiate and nonopiate effects of dynorphin. Drug Development Research 4(4): 463

Fitzpatrick, K.A.; Sinclair, D.A.; Schulze, S.R.; Syrzycka, M.; Honda, B.M., 2005: A genetic and molecular profile of third chromosome centric heterochromatin in Drosophila melanogaster. In this review, we combine the results of our published and unpublished work with the published results of other laboratories to provide an updated map of the centromeric heterochromatin of chromosome 3 in Drosophila melanogaster. To date, we can...

Middleton, L.; Ohno, K.; Christodoulou, K.; Brengman, J.; Milone, M.; Neocleous, V.; Serdaroğlu, P.; Deymeer, F.; Ozdemir, C.; Mubaidin, A.; Horany, K.; Al-Shehab, A.; Mavromatis, I.; Mylonas, I.; Tsingis, M.; Zamba, E.; Pantzaris, M.; Kyriallis, K.; Engel, A.G., 1999: Chromosome 17p-linked myasthenias stem from defects in the acetylcholine receptor epsilon-subunit gene. Objective: To identify and to characterize functionally the mutational basis of congenital myasthenic syndromes (CMS) linked to chromosome 17p. Background: A total of 37 patients belonging to 13 CMS families, 9 of them consanguineous, were investi...