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The identification of the adenosine A(2B) receptor as a novel therapeutic target in asthma


, : The identification of the adenosine A(2B) receptor as a novel therapeutic target in asthma. British Journal of Pharmacology 145(8): 1009-1015

Adenosine is a powerful bronchoconstrictor of asthmatic, but not normal, airways. In vitro studies on isolated human mast cells and basophils revealed that adenosine and selective analogues augmented inflammatory mediator release from mast cells by stimulating A(2) receptors. Pharmacological blockade of mast cell mediator release in vivo also attenuated adenosine-induced bronchoconstriction, as did theophylline, by adenosine A2 receptor antagonism.

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