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The imidazoline-like drug S23515 affects lipid metabolism in hepatocyte by inhibiting the oxidosqualene: lanosterol cyclase activity


, : The imidazoline-like drug S23515 affects lipid metabolism in hepatocyte by inhibiting the oxidosqualene: lanosterol cyclase activity. Biochemical Pharmacology 69(7): 1041-1048

Imidazoline-like drugs are centrally-acting anti hypertensive agents that inhibit the activity of the sympathetic nervous system by interacting with the alpha 2-adrenoreceptor and also with a non-adrenergic imidazoline binding site called the imidazoline I receptor. Recently, these molecules were proposed to play an additional role in cardiovascular diseases by acting on glucose and lipid metabolism.

US$19.90

PMID: 15763540

DOI: 10.1016/j.bcp.2005.01.005


Other references

Greensmith John Trevor; Tucker E.V., 1967: Morphology and evolution of inshore shell ridges and mud-mounds on modern intertidal flats, near Bradwell, Essex. The morphology, genesis and changing state of an area of mud-flats adjacent to the Dengie peninsula, Essex, are described with particular reference to mobile shell accumulations and mound-shaped mud bodies. The significance and relationship of the...

Arion V.Ya; Berkhin E.B.; Glayuteva G.I.; Ul'yanov G.P.; Sanina I.V., 1989: Effect of tactivin on the diuresis and the renal tubular transport of cardiotrast. The effect of a new immunomodulator tactivin (7-20 .mu.g/kg subcutaneously, for 6 days) on the diuresis and tubular transport of cardiotrast (diodrast) was studied on rats. Tactivin was shown to increase the tubular transport of the xenobiotic wit...

Ujiie T.; Mori M.; Ito T.; IIda Y.; Mabuchi M.; Okamura K., 1989: Application of alteromonas thalassomethanolica yk4042 for bioassay of vitamin b 12 in foods and drugs. Microbiological assay of vitamin B12 in several foods and drugs by use of a marine methanol-utilizing bacterium, Alteromonas thalassomethanolica YK4042 is described. A. thalassomethanolica required cyanocobalamin or some of its analogues for growt...

Harman, Mary T., 1908: The relation of the degree of injury to the rate of regeneration and the moulting period in the Gammarus. Indianapolis Proceedings of the Indiana Academy of Science, 1907 62-75

Anonymous, 2004: Capitalize on synergies. Apply 4(9): 7, 10-11

Terasaki, P.I.; Cannon, J.A.; Longmire, W.P., 1959: Antibody repose to homografts. I. Technic of lymphoagglutination and detection of lymphoagglutining upon spleen injection. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 102: 280-285

Kusdiana, D.S.ka, S., 2004: Effects of water on biodiesel fuel production by supercritical methanol treatment. In the conventional transesterification of fats/vegetable oils for biodiesel production, free fatty acids and water always produce negative effects, since the presence of free fatty acids and water causes soap formation, consumes catalyst and redu...

Wang, Y.; Kojetin, D.; Burris, T.P., 2015: Anti-proliferative actions of a synthetic REV-ERBα/β agonist in breast cancer cells. REV-ERBα and REV-ERBβ are nuclear receptors that are ligand-dependent transcriptional repressors. Heme is the natural ligand for these receptors, but several synthetic agonists and antagonists have been designed recently. The gene that encodes R...

Nesbitt B.E., 1991: Phanerozoic gold deposits in tectonically active continental margins. Pages 104-132 1991

Rowlands, BW., 1977: Observations of seabirds in the Falkland Islands and the Beagle Channel. Cormorant, 3: 21-23