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The immunization site of cytokine-secreting tumor cell vaccines influences the trafficking of tumor-specific T lymphocytes and antitumor efficacy against regional tumors

, : The immunization site of cytokine-secreting tumor cell vaccines influences the trafficking of tumor-specific T lymphocytes and antitumor efficacy against regional tumors. Journal of Immunology 173(10): 6025-6032

Tumor cells engineered to secrete cytokines, referred to as tumor cell vaccines, can often generate systemic antitumor immunity and, in many cases, cause tumor regression. We compared the efficacy of s.c. immunization or intrahepatic immunization of GM-CSF-expressing tumor cell vaccines on the growth of s.c. or orthotopic liver tumors. A chemically transformed hepatic epithelial cell line, GP7TB, derived from Fischer 344 rats, was used to generate,tumor models and tumor cell vaccines.


PMID: 15528337

DOI: 10.4049/jimmunol.173.10.6025

Other references

Beyer, W.; Imlay, J.; Fridovich, I., 1991: Superoxide dismutases. Progress in Nucleic Acid Research and Molecular Biology 40: 221-253

Ghadge, S.Vilas.; Raheman, H., 2005: Process optimization for biodiesel production from mahua (Madhuca indica) oil using response surface methodology. A central composite rotatable design was used to study the effect of methanol quantity, acid concentration and reaction time on the reduction of free fatty acids content of mahua oil during its pretreatment for making biodiesel. All the three vari...

O'halloran, J.; Carpenter, J.; Ogden, D.; Hogans, W.E.; Jansen, M., 1992: Atlantic Canada. Ergasilus labracis on Atlantic salmon. Canadian Veterinary Journal 33(1): 75-75

el-Silimy, O., 1993: Endonasal endoscopy and posterior epistaxis. The availability of a comprehensive range of endonasal telescopes facilitates systematic examination of the nasal cavity. Epistaxis is normally divided into anterior and posterior. Posterior epistaxis is diagnosed when anterior rhinoscopy fails to...

Chang, A.; Chen, C-Chung.; Li, H-Hung.; Li, C-Shan.R., 2015: Event-related potentials for post-error and post-conflict slowing. In a reaction time task, people typically slow down following an error or conflict, each called post-error slowing (PES) and post-conflict slowing (PCS). Despite many studies of the cognitive mechanisms, the neural responses of PES and PCS continu...

Ivanov I.V., 1970: Methane and heavy hydrocarbon distribution in steppe areas, in connection with oil and gas exploration. Trudy - Vsesoznyj Naucno-Issledovatel'skij Institut Dernoj Geofiziki i Geochimii 8: 267-275

Muthuswamy P.; Carasso B.; Sachdev V.; Remer K.S., 1987: Directly supervised ambulatory chemotherapy dsac in the management of non compliant tuberculosis patients. American Review of Respiratory Disease 135(4 PART 2): A460

Ivanov O.K.; Bulykin L.D., 1976: Compositional evolution of differentiated basaltic intrusions. Izvestiya Akademii Nauk SSSR Seriya Geologicheskaya

Szekanecz, Zán.; Soós, L.; Szabó, Zán.; Fekete, A.; Kapitány, Aó.; Végvári, Aó.; Sipka, Sándor.; Szücs, G.; Szántó, Sándor.; Lakos, G., 2008: Anti-citrullinated protein antibodies in rheumatoid arthritis: as good as it gets?. Anti-citrullinated protein antibodies (ACPAs) have recently emerged as sensitive and specific serological markers of rheumatoid arthritis (RA), providing superior alternative of the rheumatoid factor (RF) test in the laboratory diagnostics of RA....

Jennings, MR., 1988: A biography of Dr Charles Elisha Boyle, with notes on his 19th century natural history collection from California. Wasmann Journal of Biology. 1987 ; 451-2: 59-68