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The immunoglobulin A1 proteinase from Streptococcus pneumoniae is inhibited by tetracycline compounds


, : The immunoglobulin A1 proteinase from Streptococcus pneumoniae is inhibited by tetracycline compounds. Fems Immunology and Medical Microbiology 48(2): 218-222

Streptococcus pneumoniae produces a zinc-dependent proteinase that cleaves human immunoglobulin (Ig) A1 in the hinge region. This metalloproteinase is hypothesized to act as a virulence factor by allowing S. pneumoniae to evade the protection provided by IgA1, thus enhancing its ability to colonize the human nasopharyngeal region. No biologically compatible inhibitors of this enzyme have been identified. We determined that doxycycline and a chemically modified tetracycline inhibit this enzyme in vitro at low micromolar concentrations.

US$19.90

PMID: 16995879

DOI: 10.1111/j.1574-695X.2006.00148.x


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