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The immunoglobulin genes and chronic lymphocytic leukemia (CLL)

, : The immunoglobulin genes and chronic lymphocytic leukemia (CLL). Upsala Journal of Medical Sciences 110(2): 97-113

The somatic hypermutation (SMH) status of the immunoglobulin (Ig) V-H genes can divide chronic lymphocytic leukemia (CLL) into two prognostic subsets, with mutated V-H genes display superior survival compared to unmutated cases. Biased V-H gene usage has also been reported in CLL which may reflect antigen selection.


PMID: 16075892

DOI: 10.3109/2000-1967-075

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