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The immunoglobulin-like domain is involved in interaction of Neuregulin1 with ErbB


, : The immunoglobulin-like domain is involved in interaction of Neuregulin1 with ErbB. Biochemical and Biophysical Research Communications 350(2): 263-271

Neuregulin I (NRG 1) is a growth factor that signals through the interaction of the epidermal growth factor (EGF)-like domain with ErbB receptors. An immunoglobulin (1g)-like domain is contained together with EGF-like domain in the ectodomain of some isoforms generated by alternative splicing, but its role in NRGI signaling remained unclear. In the present study, we identified a novel isoform of NRGI containing an Ig-like domain conserved among species from adult Xenopus laevis, which is predominantly expressed in the testis and brain. We generated recombinant proteins for the whole ectodomain and EGF-like domain alone of the isoform to compare their effects on cell proliferation, and phosphorylation of and their association with ErbB receptor, demonstrating that the ectodomain had similar to 10(3)- fold higher abilities than the EGF-like domain. Therefore, the Ig-like domain is probably essential for efficient interaction of an EGF-like domain with ErbB receptors. (c) 2006 Elsevier Inc. All rights reserved.

US$19.90

PMID: 17007820

DOI: 10.1016/j.bbrc.2006.09.028


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