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The immunologically active site of prothymosin alpha is located at the carboxy-terminus of the polypeptide. Evaluation of its in vitro effects in cancer patients

, : The immunologically active site of prothymosin alpha is located at the carboxy-terminus of the polypeptide. Evaluation of its in vitro effects in cancer patients. Cancer Immunology, ImmunoTherapy 55(10): 1247-1257

Prothymosin alpha (proT alpha) is a 109 amino acid long polypeptide presenting distinct immunoenhancing activity in vitro and in vivo. Recent reports suggest that in apoptotic cells, proT alpha is cleaved by caspases at its carboxy(C)-terminus generating potentially bioactive fragments. In this study, we identified the peptide segment of proT alpha presenting maximum immunomodulatory activity.


PMID: 16453152

DOI: 10.1007/s00262-005-0108-4

Other references

Potter L.D.; Reynolds R.C.Jr; Louderbough E.T., 1985: Mancos shale and plant community relationships analysis of shale soil and vegetation transects. Analyses of an extensive collection of Mancos shale and derived soils from the western United States showed pH values from 3.4 to 9.4, sulfate concentrations high and widely distributed, and soil solution equilibria of gypsum and sodium-dominated...

Chen WenChang, 1998: Medium improvement for beta -fructofuranosidase production by Aspergillus japonicus. The composition of a medium for the production of intracellular beta -fructofuranosidase (EC by Aspergillus japonicus TIT-90076 was improved using statistical experimental design and the method of steepest ascent in shaken batch cultures...

Roberts, D.A.; Price, W.C., 1967: Infection of apparently uninjured leaves of bean by the viruses of tobacco necrosis and southern bean mosaic. Both viruses induced characteristic necrotic symptoms on leaves of the local-lesion bean hosts, Phaseolus vulgaris vars. Pinto and Kentucky Wonder Wax, after transport in the xylem through scalded stems and were recovered from the leaves. Necrotic...

Muley, T.; Scholz, S.; Fetz, H.; Dienemann, H.; Ebert, W., 2003: Do preoperatively elevated CYFRA 21-1 or CEA values qualify for adjuvant chemotherapy in completely resected stage I NSCLC patients?. Anticancer Research 23(6B): 4507, November-December

Gracia, A.; Giménez, F.; Giménez, M.J.; López, F., 1999: Burkitt leukemia as the presenting form of acquired immunodeficiency syndrome. Description of 2 cases. Sangre 44(3): 242-243

Ring, G.; Ganchrow, D., 1983: Projections of nucleus caudalis and spinal cord to brainstem and diencephalon in the hedgehog (Erinaceus europaeus and Paraechinus aethiopicus): a degeneration study. In the light of hypotheses related to the evolution of pain-carrying systems in mammals, terminal projection fields in brainstem and diencephalon of efferents of nucleus caudalis (NC) of the spinal trigeminal complex and spinal cord were determine...

Wang, H.; Kess, D.; Lindqvist, A-Karin.B.; Peters, T.; Sindrilaru, A.; Wlaschek, M.; Blakytny, R.; Holmdahl, R.; Scharffetter-Kochanek, K., 2008: A 9-centimorgan interval of chromosome 10 controls the T cell-dependent psoriasiform skin disease and arthritis in a murine psoriasis model. Psoriasis is a complex genetic disease of unresolved pathogenesis with both heritable and environmental factors contributing to onset and severity. In addition to a disfiguring skin inflammation, approximately 10-40% of psoriasis patients suffer f...

Arzumanyan E.A., 1985: Cow mammary gland morphology as a function of strain and lactation. Sel'skokhozyaistvennaya Biologiya (2): 92-95

Li, J.J.; Surini, M.; Catsicas, S.; Kawashima, E.; Bouras, C., 1995: Age-dependent accumulation of advanced glycosylation end products in human neurons. Glucose can react nonenzymatically with free amino groups on proteins and form advanced glycosylation end-products (AGEPs), that have been previously isolated and characterised in aging human connective tissues. In this study, we used immunocytoch...

Thomson, S.J.; Maw, B.W.; Cundriff, J.S., 1984: Automatic feedback control system for a transplant harvester based upon variable rate intermittent sampling. A prototype, hydraulically driven transplant harvester has been developed to harvest tobacco and vegetable seedlings. The mechanism lifts the plants, captures them between two strips of non-adhesive tape and rolls them into a reel. For troublefree...