geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The immunomodulatory effects of 3-monochloro-1,2-propanediol on murine splenocyte and peritoneal macrophage function in vitro


, : The immunomodulatory effects of 3-monochloro-1,2-propanediol on murine splenocyte and peritoneal macrophage function in vitro. Toxicology in Vitro 20(3): 272-278

3-Monochloro-1,2-propanediol (MCPD) is a well-known by-product of acid-hydrolyzed soy sauce during its manufacturing process. MCPD has been reported genotoxic in vitro, and reproductive toxicity and carcinogenicity in rats. To evaluate the immunomodulatory effect of MCPD on murine splenocyte and macrophage in vitro, we investigated splenocyte blastogenesis by concanavalin A (Con A), anti-CD3, and lipopolyssacharide (LPS), the production of cytokines from splenocyte, and the activity of mouse peritoneal macrophages. There was a significant decrease in lymphocyte blastogenesis to Con A or anti-CD3 at subtoxic dose of MCPD. A significant decrease in splenocyte blastogenesis to LPS was also observed. The production level of interferon (IFN)-gamma on splenocyte culture with Con A was significantly reduced at the higher concentration than 1.0 mM of MCPD. The levels of interleukin (IL)-4 and IL- 10 were also decreased at high concentrations of MCPD. There was a significant decrease in production of nitric oxide (NO) by peritoneal macrophages treated with MCPD. MCPD also inhibits tumor necrosis factor (TNF)-alpha production of stimulated macrophages. These results indicate that MCPD might be able to reduce the functionality of lymphocytes and peritoneal macrophages in vitro. (c) 2005 Elsevier Ltd. All rights reserved.

US$19.90

PMID: 16122900

DOI: 10.1016/j.tiv.2005.06.042


Other references

Bjørnstad, R.; Grøgaard, J.; Sinding-Larsen, C., 2011: Diagnosis of neck bias in children-bad practice?. Tidsskrift for den Norske Laegeforening 131(19): 1874-1874

Iversen B.M., 1991: Remission of adult steroid resistant nephrotic syndrome srns by cyclosporine a cya treatment. Journal of the American Society of Nephrology 2(3): 237

Barbieri, R.L.; Gargiulo, A.R., 2004: Metformin for the treatment of the polycystic ovary syndrome. The polycystic ovary syndrome (PCOS) is characterized by increased secretion of LH, insulin and androgens. The main clinical complaints of women with PCOS include: oligo- or amenorrhea, dysfunctional uterine bleeding, hirsutism, obesity and/or ano...

Singh, R.J.; Kollipara, K.P.; Hymowitz, T., 1987: Polyploid complexes of Glycine tabacina (Labill.) Benth. and G. tomentella Hayata revealed by cytogenetic analysis. Data from intraspecific and interspecific hybridizations revealed that the complexes of G. tabacina (2n = 40, 80) and G. tomentella (2n = 38, 40, 78, 80) had evolved through allopolyploidization. In 2n = 80 G. tabacina, 2 distinct morphological co...

Ehlers, E., 1900: Ueber atlantischen Palolo. Nachrichten von der Gesellschaft Goettingen, 397-399

Dowse, G.K.; Zimmet, P.Z.; King, H., 1991: Relationship between prevalence of impaired glucose tolerance and NIDDM in a population. Objective: To study the relationship between the prevalence of impaired glucose tolerance (IGT) and non-insulin-dependent diabetes mellitus (NIDDM) across populations of the Pacific Ocean region to assess whether variability in those two proportio...

Baldi, M.I.; Mattoccia, E.; Tocchini-Valentini, G.P., 1978: DNA supercoiling by Xenopus laevis oocyte extracts: requirement for a nuclear factor. A purified system is described for the introduction of negative supercoils into simian virus 40 DNA. The system consists of histones H2A, H2B, H3, and H4, DNA-relaxing enzyme, and a purified factor from Xenopus laevis stage 6 oocyte nuclei. The nu...

Sokolove, J.; Schiff, M.; Fleischmann, R.; Weinblatt, M.E.; Connolly, S.E.; Johnsen, A.; Zhu, J.; Maldonado, M.A.; Patel, S.; Robinson, W.H., 2016: Impact of baseline anti-cyclic citrullinated peptide-2 antibody concentration on efficacy outcomes following treatment with subcutaneous abatacept or adalimumab: 2-year results from the AMPLE trial. To examine whether baseline anti-cyclic citrullinated peptide-2 (CCP2) antibody status and concentration correlated with clinical outcomes in patients treated with abatacept or adalimumab on background methotrexate (MTX) in the 2-year AMPLE (Abata...

Kierast, E., 1922: Uber Bau und Funktion der Strukturen einzelner Protozoen und Protophyten unserer Heimat. Beitraege zur Kunde Estlands, 9: 18-21

Hirose, H., 1983: Coronary circulation with hemodynamics in orthotopically transplanted cardiac allografts of dogs. Nihon Kyobu Geka Gakkai 31(2): 181-190