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The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation


, : The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation. Experimental Cell Research 306(1): 128-141

B7-H4 protein is expressed on the surface of a variety of immune cells and functions as a negative regulator of T cell responses. We independently identified B7-H4 (DD-O110) through a genomic effort to discover genes upregulated in tumors and here we describe a new functional role for B7-H4 protein in cancer. We show that B7-H4 mRNA and protein are overexpressed in human serous ovarian cancers and breast cancers with relatively little or no expression in normal tissues. B7-H4 protein is extensively glycosylated and displayed on the surface of tumor cells and we provide the first demonstration of a direct role for B7-H4 in promoting malignant transformation of epithelial cells. Overexpression of B7-H4 in a human ovarian cancer cell line with little endogenous B7-H4 expression increased tumor formation in SCID mice. Whereas overexpression of B7-H4 protected epithelial cells from anoikis, siRNA-mediated knockdown of B7-H4 mRNA and protein expression in a breast cancer cell line increased caspase activity and apoptosis. The restricted normal tissue distribution of B7-H4, its overexpression in a majority of breast and ovarian cancers and functional activity in transformation validate this cell surface protein as a new target for therapeutic intervention. A therapeutic antibody strategy aimed at B7-H4 could offer an exciting opportunity to inhibit the growth and progression of human ovarian and breast cancers. (c) 2005 Elsevier Inc. All rights reserved.

US$19.90

PMID: 15878339

DOI: 10.1016/j.yexcr.2005.01.018


Other references

Thomas, N.R.; Peyton, S.C., 1983: An electromyographic study of mastication in the freely-moving rat. The EMG patterns of temporalis, masseter and digastric muscles of twenty Wistar white rats were studied as they ate large and small standard food pellets, bread and pudding. Bipolar EMG electrodes were placed in the muscles and led subcutaneously...

Aronson, A.S.; Garwicz, S.; Landberg, T.; Nelson, O.; Brun, A., 1975: Manifest intestinal involvement during bone-marrow remission in a case of acute lymphoblastic leukaemia. Massive leukaemic involvement of the intestine appeared in a 9-year-old girl with acute lymphoblastic leukaemia. The unusual feature in this case was that the gut involvement occurred during complete haematological remission. Surgical and subseque...

Mateos-Gil, P.; Letschert, S.; Doose, Sören.; Sauer, M., 2016: Super-Resolution Imaging of Plasma Membrane Proteins with Click Chemistry. Besides its function as a passive cell wall, the plasma membrane (PM) serves as a platform for different physiological processes such as signal transduction and cell adhesion, determining the ability of cells to communicate with the exterior, and...

Gupta, G.; Kumar, S.; Singh, R.; Shanmugasamy, K., 2010: Intussusception Caused by Yersinia enterocolitica Enterocolitis in a Patient with Sickle Cell Anemia. Yersinia enterocolitica intussusception is rarely encountered in patients without an underlying susceptibility and is most frequently reported in iron-overloaded patients. This is thought to be related to the unusual use of iron by this microorgan...

Giampalmo, A.; Badini, A.; Quaglia, A.C., 1988: Changes in the hypophysis in several autopsy cases of AIDS. Pathologica 80(1069): 627-631

Zheng, J.; Yang, Y.; Tian, S.; Chen, J.; Wilson, F.A.W.; Ma, Y., 2005: The dynamics of hippocampal sensory gating during the development of morphine dependence and withdrawal in rats. The effects of morphine on hippocampal sensory gating (N40) during the development of morphine dependence and withdrawal were investigated in the double click auditory evoked potential (EP) suppression paradigm. Rats were made dependent upon morph...

Pavlovic Stojan, 1937: Metodi termichke analize i nyena primena u mineralogiyi. Discusses the use of differential thermal analyses to determine the constituents of various minerals, especially clay minerals.

Minami, S.; Miyake, Y.; Kinoshita, H., 2016: Lipoma arborescens arising in the extra-articular bursa of the knee joint. Lipoma arborescens arising in the extra-articular bursa of the knee joint is extremely rare. We describe an 11-year-old boy who complained of a gradual swelling mass of the lateral knee joint. Magnetic resonance imaging (MRI) showed a high signal...

Hayakawa, H.; Ohnishi, M.; Shimada, H., 1993: Measuring additional dose rate contributed by nuclear plants. Monitoring systems have been constructed to measure the net additional dose rate contributed by a nuclear plant. These systems compensate for the higher dose rate due to an increase in the natural background during rainfall or from formation of an...

Pariza, M.W.; Ashoor, S.H.; Chu, F.S.; Lund, D.B., 1979: Effects of temperature and time on mutagen formation in pan-fried hamburger. Mutagenic activity generated in hamburger during pan-frying is dependent upon both temperature and time, with temperature appearing to be the more important variable. Uniformly prepared frozen hamburger pattie (115 g; 19% fat) were fried under car...