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The immunomodulatory proteins B7-DC, B7-H2, and B7-H3 are differentially expressed across gestation in the human placenta


, : The immunomodulatory proteins B7-DC, B7-H2, and B7-H3 are differentially expressed across gestation in the human placenta. American Journal of Pathology 167(2): 465-473

Placental trophoblast cells form a cellular barrier between the potentially immunogenic fetus and maternal leukocytes. Trophoblasts subvert maternal immunity by producing surface-bound and soluble factors that interact with maternal leukocytes. Here, we describe the distribution of three members of the expanding family of B7 immunomodulatory molecules: B7-DC, B7-H2, and B7-H3. B7-DC and B7-H3 inhibit antigen-stimulated lymphocyte activation while B7-H2 serves in a regulatory capacity, often promoting a Th2 immunophenotype. First trimester and term placentas, purified trophoblast cells, choriocarcinoma cell lines, and human umbilical vein endothelial cells were analyzed for B7 family RNA and protein expression. Transcripts and proteins for all three B7s were present throughout gestation but were differentially expressed within the trophoblast and the stroma. Whereas B7-DC was prominent on the syncytiotrophoblast of early placenta, it was absent from the trophoblast at term. in contrast, B7-H2 and B7-H3 were prominent on the extravillous trophoblast throughout gestation. Lastly, stromal cells, including macrophages and endothelial cells, differentially expressed B7-DC, B7-H2, and B7-H3, depending on gestational age. Thus, all three of these newly discovered B7 proteins are differentially positioned at the maternal-fetal interface such that they could steer maternal leukocytes away from a harmful immune response and toward a favorable one.

US$19.90

PMID: 16049332

DOI: 10.1016/S0002-9440(10)62990-2


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Krishna, M.Vamshi.; Prabhash, K.; Noronha, V.; Menon, S.; Dua, S.G.; Rangarajan, V.; Tangaonkar, H.B., 2012: Rare metastatic prostatic malignancy: A case report and approach to management. We present a patient with metastatic leiomyosarcoma of the prostate who achieved complete response with chemotherapy. A 70 years old male patient presented with urinary tract symptoms and a prostatic mass. After having been treated as carcinoma pr...

Wang, J.C.; Wen, S.M.; Shi, J.S.; Sun, X.L.; Li, Y.L., 1995: In vitro effects of a peptide mimetic as an antiplatelet agent. Biorheology 32(2-3): 227

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Martell, M.; Martínez, G.; González, M.; Díaz Rosselló, J.L., 1993: Suction patterns in preterm infants. The suction pattern for breast and bottle feeding in two groups of preterm infants is described. The time elapsed between birth and the moment of suction was longer in preterm neonates born at lower gestational ages for both groups studied, breast...

Arya, S.C., 1999: Prophylactic or therapeutic intervention for varicella zoster in tropical countries?. Tropical Medicine & International Health 4(4): 316-316

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Birney, M.H.; Penney, D.G., 1990: Atrial natriuretic peptide: a hormone with implications for clinical practice. The heart functions as an endocrine organ, releasing atrial natriuretic peptide (ANP), a hormone, in response to sodium and fluid overload. Specifically, ANP is released by cardiac myocytes in response to atrial distension. As a hormone, ANP has f...

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