+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The immunophilin ligand GPI1046 protects neurons from the lethal effects of the HIV-1 proteins gp120 and Tat by modulating endoplasmic reticulum calcium load

, : The immunophilin ligand GPI1046 protects neurons from the lethal effects of the HIV-1 proteins gp120 and Tat by modulating endoplasmic reticulum calcium load. Journal of Neurochemistry 98(1): 146-155

The dysfunction and death of neuronal cells is thought to underlie the cognitive manifestations of human immunodeficiency virus (HIV)-associated neurological disorders. Although HIV-infected patients are living longer owing to the effectiveness of anti-retroviral therapies, the number of patients developing neurological disorders is on the rise. Thus, there is an escalating need for effective therapies to preserve cognitive function in HIV-infected patients.


PMID: 16805804

DOI: 10.1111/j.1471-4159.2006.03863.x

Other references

Walker, V.J.; Griffin, A.P.; Hammar, D.K.; Hollenberg, P.F., 2016: Metabolism of Anandamide by Human Cytochrome P450 2J2 in the Reconstituted System and Human Intestinal Microsomes. According to the Centers for Disease Control and Prevention, the incidence of inflammatory bowel diseases (IBD) is about 1 in 250 people in the United States. The disease is characterized by chronic or recurring inflammation of the gut. Because of..., C.J.; Kline, J.C.; Contessa, P., 2015: Transposed firing activation of motor units. Muscles are composed of groups of muscle fibers, called motor units, each innervated by a single motoneuron originating in the spinal cord. During constant or linearly varying voluntary force contractions, motor units are activated in a hierarchic...

Persson Per Olof; Lundqvist Thomas, 1997: Radiometric dating of the Palaeoproterozoic Pite Conglomerate in northern Sweden. Sveriges Geologiska Undersokning, Serie C, Avhandlingar och Uppsatser 830: 41-49

Gines, A.R., 1949: Esudo actual de la hidatidosis en el Paraguay. Gines records that hydatid cysts were found in only 438 out of more than 1 1/4 million cattle slaughtered during the four years 1944 to 1947, i.e. in 0.034%. He gives notes on four human cases seen between 1942 and 1947.

Kazama, F.; Zachary, A.; Schornstein, K., 1975: Observations on Thraustochytrium sp.: development and behavior in culture. Canadian journal of botany: 53 (4) 360-374

Nayudu M.; Rolfe B.G., 1987: Analysis of r primes demonstrates that genes for broad host range nodulation of rhizobium strain ngr 234 are dispersed on the sym plasmid. R-prime plasmids carrying regions of the symbiotic (Sym) plasmid of the broad host range Rhizobium strain NGR234 were isolated in intergeneric matings with Escherichia coli K12. Three R-primes carrying approximately 180 kb (pMN23), 220 kb (pMN31)...

Elkes, J.; Waelsch, H., 1967: Heinrich Waelsch, 1905-1966. Psychopharmacologia 10(4): 285-288

Kaprelian, O.A., 2016: The questions of the clinics and therapy of pellagra in children. Pediatriia: 59-61

Tschesche, R.S.hulze, H., 1974: Triterpenes. XXX. The main saponin of the corncockle (A grostemma githago L.). Chemische Berichte: 07 (8) 2710-2719

Calnan C.J.; Schuster Gerard T., 1988: Equivalence of the CDP and earthquake tomography problems. Seismological Research Letters: , Pages 28. 1988.