geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The immunoregulatory and allergy-associated cytokines in the aetiology of the otitis media with effusion


, : The immunoregulatory and allergy-associated cytokines in the aetiology of the otitis media with effusion. Mediators of Inflammation 13(2): 75-88

Inflammation in the middle ear mucosa, which can be provoked by different primary factors such as bacterial and viral infection, local allergic reactions and reflux, is the crucial event in the pathogenesis of otitis media with effusion (OME). Unresolved acute inflammatory responses or defective immunoregulation of middle inflammation can promote chronic inflammatory processes and stimulate the chronic condition of OME. Cytokines are the central molecular regulators of middle ear inflammation and can switch the acute phase of inflammation in the chronic stage and induce molecular - pathological processes leading to the histopathological changes accompanying OME. In this review we present cytokines identified in otitis media, immunoregulatory ( interleukin (IL)-2, IL-10, transforming growth factor-beta)) and allergy associated (IL-4, IL-5, granulocyte - macrophage colony-stimulating factor), as crucial molecular regulators, responsible for chronic inflammation in the middle ear and the chronic condition of OME.

US$19.90

PMID: 15203548

DOI: 10.1080/09629350410001688477


Other references

Sukhareva, M.E., 1964: Present Status Of The Problem Of Respiratory Virus Infections In Children. Pediatriia 43: 7-14

Manley, K.; Shirley, T.L.; Flaherty, L.; Messer, A., 1999: Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice. Huntington disease (HD), an autosomal dominant, progressive neurodegenerative disorder, is caused by an expanded CAG repeat sequence leading to an increase in the number of glutamine residues in the encoded protein. The normal CAG repeat range is...

Seo S.T.; Vargas R.I.; Gilmore J.E.; Kurashima R.S.; Fujimoto M.S., 1990: Sperm transfer in normal and gamma irradiated laboratory reared mediterranean fruit flies diptera tephritidae. Normal, unirradiated females of Mediterranean fruit fly, Ceratitis capitata (Wiedemann), were mated with normal or gamma-irradiated males. In natural uninterrupted matings, mean durations in copula for normal males and irradiated males were about...

Gigantelli, J.W.; Knudtson, K.J., 2001: Rapid cold water swallowing as a clinical screening test for oculopharyngeal muscular dystrophy. IOVS 42(4): S938, March 15

Kaeser, O.; Keller, M.; Forster, R.; Wegmann, T., 1959: The chromatographic fractionation of neutral 17-ketosteroids in various forms of hypercorticism. Schweizerische Medizinische Wochenschrift 89: 415-419

Kovacs L.C.; Brozena J.M.; Lawver L.A., 1998: The Naval Research Laboratory Arctic Aerogeophysics Program, 1992-1998. Pages 105:

Sunshine, J.H.; Witkin, M.J.; Atay, J.E.; Manderscheid, R.W., 1991: Residential treatment centers and other organized mental health care for children and youth: United States, 1988. Residential treatment centers (RTCs) for emotionally disturbed children are an important component of the mental health services delivery system in the United States. The 440 RTCs operating in 1988 represented 9 percent of all mental health organi...

Tseng, J-Ruey.; Hung, J-Juh.; Huang, J-Long., 2007: The clinical differences between early-and late-onset pulmonary hemorrhage in systemic lupus erythematosus patients. Pulmonary hemorrhage (PH) is a rare but possible fatal complication of systemic lupus erythematous (SLE). We try to better understand the clinical symptoms and prognosis in patients with SLE and PH. Furthermore, we want to know whether there is di...

Naylor, D.J.; Hartl, F.U., 2001: Contribution of molecular chaperones to protein folding in the cytoplasm of prokaryotic and eukaryotic cells. While it is clear that many unfolded proteins can attain their native state spontaneously in vitro, the efficiency of such folding is usually limited to conditions far removed from those encountered within cells. Two properties of the cellular env...

Adams, J.L.; Byrne, D.; Pepe, R.; Gray, A.; Baxter, J.D., 2015: Virological failure in two patients with HIV-1 RNA viral loads >1,000,000 copies/ml initiated on elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate. Very high baseline HIV-1 RNA viral loads require potent and robust antiretroviral regimens to achieve virological suppression. The coformulated single tablet regimen of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate (EVG/COBI/...