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The immunosuppressant and hyperplasia-inducing drug cyclosporin A regulates the cell cycle and cyclin B1 gene expression in gingival fibroblasts in vitro


, : The immunosuppressant and hyperplasia-inducing drug cyclosporin A regulates the cell cycle and cyclin B1 gene expression in gingival fibroblasts in vitro. Cell and Tissue Research 317(2): 221-225

Gingival overgrowth is a frequent and adverse side-effect caused by certain immunosuppressant, anti-convulsant and calcium channel-blocking drugs. Although the precise mechanism is not yet known, the enhanced proliferation of gingival fibroblasts observed in this disease could be caused at least partly by the effects of the drugs on the cell cycle and cyclin expression in these cells. In the present study, flow cytometry analysis of the effects of the immunosuppressant drug cyclosporin A showed that it enhanced cell-cycle progression of gingival fibroblasts in vitro and also up-regulated the expression of cyclin B1. In addition, reverse transcriptase/polymerase chain reaction analysis of gingival overgrowth tissues showed markedly elevated transcription of the cyclin B1 gene. Thus, the increase in cell growth that occurs in drug-induced gingival overgrowth may be mediated by over-expression of cyclin B1.

US$19.90

PMID: 15221438

DOI: 10.1007/s00441-004-0909-3


Other references

Jones, H.R.A.; Barnes, J.; Tuomi, M.; Jenkins, J.S.; Anglada-Escude, G., 2014: Radial velocity studies of cool stars. Our current view of exoplanets is one derived primarily from solar-like stars with a strong focus on understanding our Solar System. Our knowledge about the properties of exoplanets around the dominant stellar population by number, the so-called l...

Osame, M., 2002: Pathological mechanisms of human T-cell lymphotropic virus type I-associated myelopathy (HAM/TSP). The recent studies have greatly improved our understanding of the pathological mechanisms of human T cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The pathological mechanisms of HAM/TSP based...

Andrea, M.-De; Ruegg, E., 1982: Degradation of 14C carbon isotope parathion in vitro by microorganisms isolated from a Gley Humic soil.1. Revista brasileira de ciencia do solo 6(2): 94-98

Vonier, P.M.; Guillette, L.J.; McLachlan, J.A.; Arnold, S.F., 1997: Identification and characterization of estrogen and progesterone receptors from the oviduct of the American alligator (Alligator mississippiensis). A protein extract prepared from the egg shell fiber-secreting region of the oviduct of Alligator mississippiensis was assayed for the presence of receptors for estrogen and progesterone. In the presence of [3H]-estradiol-17 beta, the extract conta...

Tak, R.; Semmekrot, B.; Warris, A.; Yntema, J.Bart.; Stelma, F.; Neeleman, C., 2016: Bacterial Tracheitis and Septic Shock. Pediatric Infectious Disease Journal 35(2): 226-227

Blyth George Henry, 1942: Intrusive igneous rocks of the Shelve area, south Shropshire. Geol Soc

Connolly, M.; Mullan, R.H.; McCormick, J.; Matthews, C.; Sullivan, O.; Kennedy, A.; FitzGerald, O.; Poole, A.Robin.; Bresnihan, B.; Veale, D.J.; Fearon, U., 2012: Acute-phase serum amyloid A regulates tumor necrosis factor α and matrix turnover and predicts disease progression in patients with inflammatory arthritis before and after biologic therapy. To investigate the relationship between acute-phase serum amyloid A (A-SAA) and joint destruction in inflammatory arthritis. Serum A-SAA and C-reactive protein (CRP) levels, the erythrocyte sedimentation rate (ESR), and levels of matrix metallopro...

Rosenstadt, E., 1895: Ueber den gegenwartigen Stand der Befruchtungs-lehre. Wiener Medizinische Blaetter, XVIII 360-363

Yamaguchi N., 1970: Experimental studies on the hormonal regulation of lipid metabolism by using carbon 14 labeled substances part 2 influence of adreno cortical function on metabolism of the fatty acid and cholesterol. Folia Endocrinol Jap 46(4): 370-371, 463-476

Babeev, A.A.; Kazachok, G.E.; Efimov, V.I., 1992: Use of pigs of the SM-1 type for crossbreeding. Four groups, each of 20 Russian Large White (RLW) sows, were inseminated resp. with semen from RLW boars or from Soviet Meat boars of the Southern (Krasnodar) type or of 2 Steppe types (Rostov and Stavropol). For the 4 groups resp., litter size av...