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The impact and outcome of transplant coronary artery disease in a pediatric population: a 9-year multi-institutional study

, : The impact and outcome of transplant coronary artery disease in a pediatric population: a 9-year multi-institutional study. Journal of Heart and Lung Transplantation 24(6): 645-651

Background: Transplant coronary artery disease (TCAD) limits survival in heart transplant recipients; however, its incidence in children is unknown. The purpose of this study was to determine the angiographic incidence of TCAD, potential risk factors, and outcomes in a large pediatric cohort.Methods: From January 1993 to December 1, a total of 1,222 children, aged newborn to 17 years, underwent primary cardiac transplantation at 20 institutions. A total of 2,049 coronary angiograms were performed in 751 patients. All angiograms were graded for coronary disease and results were submitted to the Pediatric Heart Transplant Study database. We analyzed time-related freedom from graded severity and events from coronary disease, and we examined risk factors.Results: The incidence of angiographic abnormalities at 1, 3, and 5 years was 2%, 9%, and 17.%, respectively; however, moderate-to-severe disease occurred in only 6% at 5 years, compared with 15% in the adult transplant database (p < 0.0001). The major risk factors were older recipient and donor age. Two or more episodes of rejection in the 1st year correlated with coronary disease (p = 0.05). Overall freedom from graft loss caused by primary TCAD was 99%, 96%, and 91% at 1, 5, and 9 years after heart transplantation, respectively. Death or graft loss occurred within 2 years of diagnosis in patients with severe disease; 24% of patients with any coronary disease died within 2 years.Conclusions: The incidence of TCAD in children is smaller than the incidence in adults, but increases with age. Graft loss is infrequent in children; however, severe coronary disease correlates with poor prognosis. (c) 2005 by the International Society for Heart and Lung Transplantation.


PMID: 15949722

DOI: 10.1016/j.healun.2004.03.021

Other references

Lorand L., 1972: Fibrin stabilizing factor inhibitors part 4 action of some synthetic fibrino ligase inhibitors on human platelet aggregation. Journal Of Medicinal Chemistry: 98-99

Wali, M.C.; Mahadevappa, M.; Krishna Murthy, R.A., 1998: Ratoon crop performance of experimental rice hybrids in Karnataka. Eight hybrids plus 3 controls were evaluated for ratooning performance during kharif 1992. Highest ratooning ability and increased yields were noted in the hybrid IR-54752A/ARC-11353, followed by hybrids having the same maternal parent IR-54752A....

Goncharova E.I., 1980: The role of mathematics in forming the concepts and theoretical ideas of geology. Soviet Geology and Geophysics 21(7): 65-72

An, Y.; Kang, J., 2016: Relationship between Organizational Culture and Workplace Bullying among Korean Nurses. To identify the relationship between organizational culture and experience of workplace bullying among Korean nurses. Participants were 298 hospital nurses in Busan, South Korea. We assessed nursing organizational culture and workplace bullying am...

Hejchman, E.; Haugwitz, R.D.; Cushman, M., 1995: Synthesis and cytotoxicity of water-soluble ambrosin prodrug candidates. The potential therapeutic application of the naturally occurring, cytotoxic pseudoguaianolide sesquiterpene lactone ambrosin is limited by its aqueous insolubility. A number of water- soluble ambrosin derivatives have therefore been prepared for p...

Rouf M.A.; Galassie V.R.; Kuehner K.P.; Parker D.L., 1975: Effect of glucose concentration on glucose metabolism when uric acid is the nitrogen source for aerobacter aerogenes and pseudomonas fluorescens. Science of Biology Journal 1(1): 4-9

Darkwah, L.; Rowson, N.A.; Hewitt, C.J., 2005: Laboratory scale bioremediation of acid mine water drainage from a disused tin mine. Real acidic mine-water drainage was seeded with Acidithiobacillus ferrooxidans to catalyse the removal of iron contained therein. The addition of At. ferrooxidans increased metal precipitation kinetics and decreased the water iron content by ~70%....

Anonymous, 2012: Egyptian Rice Export Ban Spurs Smuggling. Egypt’s ban on rice exports hasn’t slowed the flow of rice out of Egypt so much as diverted export flows from legitimate traders to smugglers. The nation’s rice export ban was intended to ensure Egyptians would have enough rice f...

Mohacsi, K., 1984: The organization and financial regulation of agricultural exports. Hungarian export companies, determined to promote exports, should form joint ventures with other companies in an effort to reduce risk. This paper considers whether these export companies have sufficient financial resources to form such joint vent...

Symmmons P.M.; Mcculloch L., 1980: Persistence and migration of chortoicetes terminifera orthoptera acrididae in australia. Examples of the persistence of adult infestations of C. terminifera (Wlk.) in Australia were contrasted with ones where mass displacement took place. Migration occurred if sufficient rain had fallen at the nymphal stage to produce green pasture; p...