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The impact of ATP-sensitive K+ channel subtype selectivity of insulin secretagogues for the coronary vasculature and the myocardium


, : The impact of ATP-sensitive K+ channel subtype selectivity of insulin secretagogues for the coronary vasculature and the myocardium. Diabetes 53 Suppl 3: S156-S164

Insulin secretagogues (sulfonylureas and glinides) increase insulin secretion by closing the ATP-sensitive K+ channel (KATP channel) in the pancreatic beta-cell membrane. KATP channels subserve important functions also in the heart. First, KATP channels in coronary myocytes contribute to the control of coronary blood flow at rest and in hypoxia. Second, KATP channels in the sarcolemma of cardiomyocytes (sarcKATP channels) are required for adaptation of the heart to stress.

US$19.90

PMID: 15561904

DOI: 10.2337/diabetes.53.suppl_3.S156


Other references

Segal, J., 1988: Adrenergic inhibition of the stimulatory effect of 3,5,3'-triiodothyronine on calcium accumulation and cytoplasmic free calcium concentration in rat thymocytes. Further evidence in support of the concept that calcium serves as the first messenger for the prompt action of thyroid hormone. Thyroid hormone produces a prompt, plasma membrane-mediated increase in several metabolic functions in the rat thymocyte. These effects of thyroid hormone require calcium and are inhibited by the .beta.-adrenergic antagonist alprenolol. In the pre...

Habjorg, A., 1980: Trials using Poa pratensis L. as a lawn grass. Gartneryrket 70(18): 531-535

Weimar R.H., 1973: Toward a model of primary prevention of drug abuse in elementary schools a final draft of a report submitted to the training program in the field of drug addiction washingtonian center for addictions and boston state hospitals drug addiction rehabilitation center boston massachusetts. British Journal Of Addiction: 57-63

Itziou, A.; Dimitriadis, V.K., 2012: Effects of organic pollutants on Eobania vermiculata measured with five biomarkers. In the present study, the effect of organic pollution on land snails <i>Eobania vermiculata</i> was investigated. Five pollution biomarkers (neutral red retention assay, morphometry of lysosomes and neutral lipids, acetylcholinesterase...

Arakawa, M.; Kanai, H.; Ishikawa, K.; Nagaoka, R.; Kobayashi, K.; Saijo, Y., 2017: A method for the design of ultrasonic devices for scanning acoustic microscopy using impulsive signals. Scanning acoustic microscopy (SAM) using impulsive signals is useful for characterization of biological tissues and cells. The operating center frequency of an ultrasonic device strongly depends on the performance characteristics of the device if...

Campbell, D., 1978: David Campbell. Lancet 2(8079): 55-55

Amako, K.; Umeda, A., 1977: An improved method for observation of bacterial growth using the scanning electron microscope. Improvements in a method for growing bacteria on a thin agar layer formed on the surface of a membrane filter are reported. Using these improvements, scanning electron microscopy of growth of Streptococcus haemolyticus and outgrowth of Bacillus su...

Brooks, G.F.; Donegan, E.A.; Penn, C.W.Reviewer, 1986: Gonococcal infection (book review). The Journal of Applied Bacteriology 60: 3-4

Krej, M.; Dziuda, L.; Skibniewski, F.Wojciech., 2016: A method of detecting heartbeat locations in the ballistocardiographic signal from the fiber-optic vital signs sensor. We present a flexible, easy-to-expand digital signal processing method for detecting heart rate (HR) for cardiac vibration signals of fiber Bragg grating (FBG) sensor. The FBG-based method of measuring HR is possible to use during the magnetic res...

Lee, S-Young.; Teoh, P.J.; Camm, C.F.; Agha, R.A., 2013: Compliance of randomized controlled trials in trauma surgery with the CONSORT statement. Randomized controlled trials (RCTs) are the criterion standard for assessing new interventions. However, bias can result from poor reporting, which also makes critical appraisal and systematic review challenging. The Consolidated Standards of Repo...