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The impact of CYP2D6 genotypes on the plasma concentration of paroxetine in Japanese psychiatric patients


, : The impact of CYP2D6 genotypes on the plasma concentration of paroxetine in Japanese psychiatric patients. Progress in Neuro-Psychopharmacology & Biological Psychiatry 30(3): 486-491

The authors investigated the impact of the CYP2D6 genotypes on the plasma concentration of paroxetine (PAX) in 55 Japanese psychiatric patients. They were administered 10 to 40 mg/day (24 +/- 10.0 mg/day) of PAX and maintained at the same daily dose for at least two weeks to obtain the steady-state concentrations. The plasma levels of PAX were 15.8 +/- 15.0, 47.4 +/- 32.0, 101.2 +/- 59.9 and 177.5 +/- 123.6 ng/ml at the daily dose of 10, 20, 30 and 40 mg, respectively, which suggested dose dependent kinetics of PAX. The allele frequencies of the CYP2D6*5, CYP2D6*10 and CYP2D6*41 were 1.8%, 41.8% and 1.8%, respectively. Significantly higher PAX concentrations were observed in the patients having one functional allele compared with those with two functional alleles (150.9 +/- 20.6 vs. 243.6 +/- 25.2 ng/ml mg(-1) kg(-1),p < 0.05, NewmanKeuls multiple comparison test) or no functional (243.6 +/- 25.2 vs. 76.7 +/- 6.1 ng/mI mg(-1) kg(-1), p < 0.05, Newman-Keuls multiple comparison test) in the subjects with 30 mg/day of paroxetine. The same trend of findings as in the subjects treated with 30 mg/day were observed in the subjects with 40 mg/day of PAX. The present results suggest that having one non-functional allele is the marker for high plasma concentration of PAX when relatively high daily dose of PAX is administered. (c) 2005 Elsevier Inc. All rights reserved.

US$19.90

PMID: 16423440

DOI: 10.1016/j.pnpbp.2005.11.007


Other references

Sunderland, D.W.; Merrett, M.J., 1964: Adenosine Diphosphate And Adenosine Triphosphate Concentrations In Leaves Showing Necrotic Local Virus Lesions. Virology 23: 274-276

Gibson John A.E.; Trull Tom; Nichols Peter D.; Summons Roger E.; McMinn Andrew, 1999: Sedimentation of super 13 C-rich organic matter from Antarctic sea-ice algae; a potential indicator of past sea-ice extent. Organic matter collected in sediment traps at a nearshore marine site in Prydz Bay, East Antarctica, displayed a pronounced seasonal variation in carbon isotopes (expressed as delta (super 13) C (sub OM) ). Winter values were fairly constant near...

Rees, R.B., 1976: Full-time Attention to Medical Problems. Western Journal of Medicine 125(3): 235-235

A.J.nabi M.A.A.; Moussa S.O., 1985: Labeling of human serum albumin millimicrospheres with technetium 99m. Journal of Radioanalytical & Nuclear Chemistry 88(2): 403-406

Selleck Bruce W.; Linsley Robert M., 1984: Sedimentology and faunal assemblages in the Hamilton Group of central New York. Annual Meeting of the New York State Geological Association 56: 221-236

Lau, A.K.; Chaufour, X.; McLachlan, C.; Leichtweis, S.B.; Celermajer, D.S.; Sullivan, C.; Stocker, R., 2005: Intimal thickening after arterial balloon injury is increased by intermittent repetitive hypoxia, but intermittent repetitive hyperoxia is not protective. Hypoxia increases and hyperoxia decreases experimental atherosclerosis, but it is unclear if repetitive hypoxic and hyperoxic insults affect intimal thickening after arterial injury. Rabbits on 2% cholesterol diet for 6 weeks underwent balloon inj...

Kydyrmaev, A.K.; Kvitko, A.Z., 1974: Most important characteristics of cows in selection for suitability for machine milking. Of 205 Ala-Tau heifers on 3 state farms in the Kirgiz mountains, 24 (11.7%) had vat-shape udders, 100 (48.8%) had cup-shape udders, 68 (33.1%) had round-shape udders, and 13 (6.4%) had goats' udder-shape udders. Mean daily milk yields were re...

Field J.B.; Ealey P.A.; Marshall N.J.; Cockcroft S., 1987: Tsh stimulates increases in inositol phosphates as well as cyclic amp in the frtl 5 rat thyroid cell line. Studies were conducted to determine whether thyroid-stimulating hormone (TSH; thyrotropin), a hormone known to increase cytosol concentrations of cyclic AMP, also stimulates the formation of inositol phosphates in thyroid cells. TSH and noradrenal...

Bello, M.Josefa.; Alonso, M.Eva.; Amiñoso, C.; Anselmo, N.P.; Arjona, D.; Gonzalez-Gomez, P.; Lopez-Marin, I.; de Campos, J.M.; Gutierrez, M.; Isla, A.; Kusak, M.Elena.; Lassaletta, L.; Sarasa, J.L.; Vaquero, J.; Casartelli, C.; Rey, J.A., 2004: Hypermethylation of the DNA repair gene MGMT: association with TP53 G:C to A:T transitions in a series of 469 nervous system tumors. O6-methylguanine-DNA methyltransferase (MGMT) plays a major role in repairing DNA damage from alkylating agents. By removing alkyl groups from the O6-position in guanine, MGMT can prevent G:C to A:T transition mutations, a type of variation freque...

Bauersachs J.; Galle J.; Busse R.; Bassenge E., 1992: Oxidized low density lipoproteins inhibit dilations mediated by cyclic nucleotides in human and rabbit arteries. FASEB Journal 6(4): A1030