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The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stability


, : The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stability. Journal of Experimental Medicine 203(5): 1319-1328

DM edits the peptide repertoire presented by major histocompatibility complex class II molecules by professional antigen-presenting cells (APCs), favoring presentation of some peptides over others. Despite considerable research by many laboratories, there is still significant uncertainty regarding the biochemical attributes of class II - peptide complexes that govern their susceptibility to DM editing. Here, using APCs that either do or do not express DM and a set of unrelated antigens, we found that the intrinsic kinetic stability of class II - peptide complexes is tightly correlated with the effects of DM editing within APCs. Furthermore, through the use of kinetic stability variants of three independent peptides, we demonstrate that increasing or decreasing the kinetic stability of class II - peptide complexes causes a corresponding alteration in DM editing. Finally, we show that the spontaneous kinetic stability of class II complexes correlates directly with the efficiency of presentation by DM+ APCs and the immunodominance of that class II - peptide complex during an immune response. Collectively, these results suggest that the pattern of DM editing in APCs can be intentionally changed by modifying class II - peptide interactions, leading to the desired hierarchy of presentation on APCs, thereby promoting recruitment of CD4 T cells specific for the preferred peptides during an immune response.

US$19.90

PMID: 16682499

DOI: 10.1084/jem.20060058


Other references

Tippett, D.C., 2011: Clinical challenges in the evaluation and treatment of individuals with poststroke dysphagia. Although reported frequencies vary due to study design, patient characteristics, and method of ascertainment, dysphagia is a commonly encountered morbidity after stroke. Consequently, speech-language pathologists' clinical caseloads are heavi...

Suganuma, M.; Marugami, Y.; Sakurai, Y.; Ochiai, M.; Hasegawa, S.; Imazu, H.; Matsubara, T.; Funabiki, T.; Kuroda, M., 1998: Cardiac metastasis from squamous cell carcinoma of gallbladder. A 65-year-old woman was admitted to our hospital with the diagnosis of gallbladder tumor. Right extended hepatic lobectomy plus lymph node dissection of the hepatoduodenal ligament and left hepaticojejunostomy with Roux-en-Y reconstruction was per...

Iqbal, S.; McCoy, S.; Lenz, H.J.; Rivkin, S.E.; Atkins, J.N.; Blanke, C.D., 2016: SWOG S0202: A phase II trial of gemcitabine and capecitabine in patients (pts) with unresectable or metastatic gallbladder cancer or cholangiocarcinoma. NlmCategory="UNASSIGNED">4134 Background: Pts with gallbladder cancer or cholangiocarcinoma usually present with advanced disease and limited treatment options. Based on data demonstrating effectiveness of gemcitabine in pancreatic ca...

Sachin Malde; Nitin Shrotri, 2012: Undergraduate urology in the UK Does it prepare doctors adequately?. Undergraduate medical education in the UK has recently changed. Medical schools are expected to provide the core knowledge required for medical practice, with the foundation programme building upon this. However, studies have suggested that both u...

Katsivas, A.; Koutouzis, M.; Nikolidakis, S.; Lazaris, E.; Arealis, G.; Kyriakides, Z.S., 2006: Persistent left superior vena cava associated with common type AV nodal reentrant tachycardia and AV reentrant tachycardia due to concealed left lateral accessory pathway. International Journal of Cardiology 113(3): E124-E125

Kim, B.Guk.; Oh, J-Hoon.; Choi, H.Na.; Park, S.Young., 2015: Simple assessment of olfaction in patients with chronic rhinosinusitis. The brief-smell identification test (B-SIT) can substitute for the butanol threshold test (BTT) in screening of anosmia and postoperative assessment of olfactory outcomes in patients with chronic rhinosinusitis (CRS). A time-effective test battery...

Richards, J.S.; Kirchick, H.J., 1984: Changes in content and phosphorylation of cytosol proteins in luteinizing ovarian follicles and corpora lutea. Cytosol prepared from rat preovulatory ovarian follicles contained several specific substrates which were phosphorylated by [gamma 32P] ATP in the presence of 2 microM cyclic AMP (cAMP) or 780 nM of highly purified catalytic subunit. These substra...

Schmetzer Karl; Medenbach O., 1983: Challantite from Cache Creek, British Columbia; second discovery. Neues Jahrbuch fuer Mineralogie Monatshefte

Sta, Y., 1951: Progress in the biological application of isotopes. Turk Tip Cemiyeti Mecmuasi 17(3): 104-111

Wielosz M., 1981: Increased sensitivity to dopaminergic agonists after repeated electro convulsive shock in rats. The effects of single or repeated electroconvulsive shock (once daily for 7 days) on spontaneous locomotor activity and dopamine agonist-induced hyperactivity were investigated 1 h, 1, 5 and 10 days after the last shock. Apomorphine-induced stereo...