+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The impact of DNA damage, genetic mutation and cellular responses on cancer prevention, longevity and aging: observations in humans and mice

, : The impact of DNA damage, genetic mutation and cellular responses on cancer prevention, longevity and aging: observations in humans and mice. Mechanisms of Ageing and Development 126(1): 71-77

Over the past 5 years. data collected from the mouse suggest that pathways important for either preventing or resolving DNNA damage are longevity assurance mechanisms whose critical overall function is somatic cell maintenance. a necessary pan of cancer prevention. These pathways include those that reduce DNA damage levels caused by exogenous sources. replication errors and by-products of cellular respiration. Unresolved DNA damage leads to permanent mutations in the genetic code that may be oncogenic. Therefore. pathways that resolve DNA damage are important anti-cancer mechanisms. As an important line of defense, there are a variety of pathways that repair DNA damage. In addition, there are anti-cancer pathways that respond to DNA damage by either preventing cellular replication or inducing cell death. Genes in these pathways, termed longevity assurance genes (LAG), code for proteins that reduce cancer incidence and as a result assures a sufficiently long health span needed for reproduction. Data from mouse models, many that were originally designed to study cancer. are showing that a potential consequence of DNA damage and responses to DNA damage is aging: these models support the hypothesis that at least some aspects of normal aging are the consequence of anticancer mechanisms designed to deal with damaged DNA. Copyright 2004 Elsevier Ireland Ltd. All rights reserved.


PMID: 15610764

DOI: 10.1016/j.mad.2004.09.036

Other references

Duntas L.; Lenz C.; Keck F.S.; Wolf C.; Rosenthal J., 1991: Pharmacokinetic properties of thyrotropin releasing hormone thr in chronic renal insufficiency. European Journal of Clinical Investigation 21(2 PART 2): 28

McClure, R.Scott.; Cohn, L.H.; Wiegerinck, E.; Couper, G.S.; Aranki, S.F.; Bolman, R.Morton.; Davidson, M.J.; Chen, F.Y., 2009: Early and late outcomes in minimally invasive mitral valve repair: an eleven-year experience in 707 patients. This study analyzes a single institution experience with minimally invasive mitral valve repair and evaluates long-term surgical outcomes of morbidity, mortality, and rates of reoperation. Late follow-up of mitral regurgitation and left ventricula...

Buttery, C.M., 1994: The south Richmond health status survey. Virginia Medical Quarterly 121(4): 218-219

Akama, H.; Noshiro, T.; Kimura, N.; Shimizu, K.; Watanabe, T.; Shibukawa, S.; Nakai, S.; Miura, W.; Ito, S.; Miura, Y., 1999: Multiple endocrine neoplasia type 2A with the identical somatic mutation in medullary thyroid carcinoma and pheochromocytoma without germline mutation at the corresponding site in the RET proto-oncogene. A germline mutation either in exon 10 or 11 of the RET proto-oncogene is found in the majority of patients with multiple endocrine neoplasia type 2A (MEN 2A). A 41-year-old female patient was referred for further evaluation of incidentally discove...

Markova, M.; Peneff, C.; Hewlins, M.J.E.; Schirmer, T.; John, R.A., 2005: Determinants of substrate specificity in omega-aminotransferases. Ornithine aminotransferase and 4-aminobutyrate aminotransferase are related pyridoxal phosphate-dependent enzymes having different substrate specificities. The atomic structures of these enzymes have shown (i) that active site differences are limi...

Chen CaiLin; Zhou GuangFan; Fan YongHong; Zhou Yuan; Chen XueQun, 1995: Discussion on the origin of mustard (Brassica juncea) in China. The origin and development of B. juncea in China are discussed under the following headings: current situation of study on the origin of mustard; the historical literature of the origin and development of mustard in China; surviving [survey?] and...

Karita, K.; Takahashi, H.; Yasui, T.; Izumi, H., 1995: Effects of the autonomic ganglion blocking agent hexamethonium on vasodilator responses mediated by the parasympathetic ganglion on the chorda tympani pathway of the cat. We investigated the pharmacological properties of a parasympathetic ganglion (a chorda tympani ganglion) that mediates vasodilator responses in the lower lip induced by electrical stimulation of the distal cut end of the chorda tympani or facial n...

Moreva, T.V.; Anisimova, L.A.; Erova, T.E.; Boronin, A.M., 1992: Amikacin resistance in clinical strains of Enterobacteriaceae and Pseudomonas. Amikacin resistance was studied in 380 bacterial strains of Enterobacter, Klebsiella, Serratia, Pseudomonas and Escherichia coli isolated in clinics of the Moscow Region. It was shown that 69 isolates were resistant to amikacin. Plasmid DNA was de...

Kazmin, A.I., 1963: On The Problem Of The Stability Of Spinal Deformities In Scoliosis. Ortopediia Travmatologiia i Protezirovanie 24: 11-12

Dolan, J.W.; Seiber, J.N., 1977: Chlorine selective detection for liquid chromatography with a coulson electrolytic conductivity detector. The design and operation of a liquid chromatography/Coulson electrolytic conductivity detector (CECD) analytical system are described. Vydac totally porous reversed phase column effluent (aqueous methanol) was introduced to the CECD quartz combust...