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The impact of a new immunomodulator oxo-quinoline-3-carboxamide on the progression of experimental lupus


, : The impact of a new immunomodulator oxo-quinoline-3-carboxamide on the progression of experimental lupus. International Immunopharmacology 4(12): 1515-1523

Autoimmune, lupus-prone MRL lpr/lpr mice were treated orally with oxo-quinoline-3-carboxamide (ABR-25757), a newly developed immunomodulator. Treatment was initiated in one set of experiment at the age of 10 weeks, before the onset of clinically apparent disease, and in another set at 15 weeks, after the development of established lupus disease. Beneficial therapeutic effects were obtained even when ABR-25757 was administered at the lowest dose tested (7.5 mug/mouse/week) to 15 weeks old mice with established lupus disease. The effects of ABR-25757 on longevity, as well as on development of glomerulonephritis were pronounced and comparable with those of LS-2616, a potent immunomodulator. Administration of ABR-25757 did not significantly alter T cell responses in vivo nor in vitro. In addition, it only marginally suppressed B cell responses measured as frequencies of immunoglobulin secreting cells. By the same token this compound did not affect overall leukocyte content in primary (bone marrow) or secondary (spleen) lymphoid tissues. In contrast, treatment with ABR-25757 up regulated expression of pro-inflammatory transcription factors NF-kappaB and AP-1. These results suggest (a) a potential therapeutic role of ABR-25757 in the treatment of experimental lupus and (b) that the effect of the treatment is mediated by immunodeviation rather than by immunosuppression. Copyright 2004 Elsevier B.V. All rights reserved.

US$19.90

PMID: 15351320

DOI: 10.1016/j.intimp.2004.07.009


Other references

Kleines, M.; Nellessen, M.; Schaade, L.; Ritter, K., 2003: In vitro cell free synthesis of human manganese superoxide dismutase with the RTS 500 system. Reduced activity of manganese superoxide dismutase (MnSOD) is the basis of several pathologic features and complications occurring in the course of infectious mononucleosis. In order to supply future research with easily accessible enzyme, an in v...

Backes, C.H.; Rivera, B.K.; Bridge, J.A.; Armstrong, A.K.; Boe, B.A.; Berman, D.P.; Fick, T.; Holzer, R.J.; Hijazi, Z.M.; Abadir, S.; Justino, H.; Bergersen, L.; Smith, C.V.; Kirpalani, H., 2017: Percutaneous Patent Ductus Arteriosus (PDA) Closure During Infancy: A Meta-analysis. Patent ductus arteriosus (PDA) is a precursor to morbidity and mortality. Percutaneous (catheter-based) closure is the procedure of choice for adults and older children with a PDA, but use during infancy (<1 year) is not well characterized. Inv...

Varin J.; Duboc D.; Lim C.; Weber S.; Maistre G.; Gros C.; Schwartz J C.; Lecomte J M.; Carayon A.; E.A., 1989: Enhancement of atrial natriuretic factor in congestive heart failure by sinorphan an enkephalinase inhibitor. Circulation 80(4 SUPPL 2): II111

L.V.cchia, C.; Negri, E.; Bruzzi, P.; Dardanoni, G.; Decarli, A.; Franceschi, S.; Palli, D.; Talamini, R., 1992: The role of age at menarche and at menopause on breast cancer risk: combined evidence from four case-control studies. The role of age at menarche and at menopause on breast cancer risk was reassessed in a combined analysis of four Italian case-control studies including a total of 6,075 cases and 5,492 controls. The risk of breast cancer was lower in women whose m...

Wittman F., 1973: Fracture mechanism in rocks in long-term conditions. International Journal of Rock Mechanics and Mining Sciences 4(4): 116

Esteban, J.I.; Genesca, J.; Alter, H.J., 1992: Hepatitis C: molecular biology, pathogenesis, epidemiology, clinical features, and prevention. Progress in Liver Diseases 10: 253-282

Bisagni Faure, A.; Job Deslandre, C.; Assous, M.; Menkes, C.J., 1992: Immune response to 3 different strains of Borrelia burgdorferi in patients with Lyme arthritis Correlation between reactivity to outer-surface proteins A and B and clinical pattern. Arthritis & Rheumatism 35(9 SUPPL ): S184

Hancock, J., 1984: Aerial stretch display of the eastern race of the great white egret Egretta alba. Ibis, 1261: 92-94

Lotfi, E.; Neek-Amal, M., 2017: Temperature distribution in graphene doped with nitrogen and graphene with grain boundary. Graphene doped with nitrogen exhibits unique properties different than perfect graphene. The temperature distribution in nitrogen-doped graphene (N-graphene) and in the graphene with grain boundary is investigated using molecular dynamics simulati...

McElroy Brandon; Wilkinson Bruce, 2005: Climatic control of continental physiography. The spatial distribution of elevations and slopes on continents is a primary expression of complex interactions between tectonic and climatic systems. Because rates of tectonism and climatically mediated erosion vary in both space and time, it is...