+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The impact of barriers to hepatitis C virus treatment in recovering heroin users maintained on methadone

, : The impact of barriers to hepatitis C virus treatment in recovering heroin users maintained on methadone. Journal of Substance Abuse Treatment 29(3): 159-165

Although most cases of hepatitis C virus (HCV) infection are associated with injection drug use, there are few data regarding the impact of putative barriers such as psychiatric disease and intercurrent drug use on HCV treatment outcomes. To define the impact of characteristics often cited as reasons for withholding HCV treatment, we studied HCV treatment in a real world sample of 76 recovering heroin users maintained on methadone. Overall, 21 (28%) had a sustained virological response and 18 (24%) discontinued treatment early. Although there was a modest decrement in response rates in patients reporting a preexisting psychiatric history (p =.01), neither intercurrent drug use nor short duration of pretreatment drug abstinence led to significant reductions in virological outcomes (p =.09 and p =.18, respectively.) We conclude that injection drug users can be safely and effectively treated for HCV despite multiple barriers to treatment when they are treated in a setting that can address their special needs. (c) 2005 Elsevier Inc. All rights reserved.


PMID: 16183464

DOI: 10.1016/j.jsat.2005.06.002

Other references

Jankiewicz, L.S.; E.A., 1961: The use of auxin to widen crotch angles in young apple trees. A lanolin paste containing potassium salt of indoleacetic acid was used to widen crotch angles in 2-year-old Macoun and Starting apple trees grown in a nursery. Three concentrations of an auxin in the paste were used 0.5%, 1%, 2%. Several groups o...

Fu, S.J.; Weng, N.Q., 1989: Retinal detachment associated with coloboma of choroid. Retinal detachment associated with congenital coloboma of choroid is an unusual type of the disease 32 cases (34 eyes), or 1.23% of all 2,602 cases of retinal detachment, were operated on during 1980 to 1986. 17 (53%) patients were under 20 years...

Crampton, C.; Rohde, C.; Van-Wagoner, K., 1985: Cereal variety testing. Special report Oregon State University Agricultural Experiment Station: (738) 65-68

Cipes, M.H.; Kegeles, S.S.; Lund, A.K.; Otradovec, C.L., 1983: Differences in dental experiences, practices, and beliefs of inner-city and suburban adolescents. Inner-city and suburban students' dental experiences, current practices, beliefs, and compliance with two school-based preventive programs were examined. Striking differences were found in the students' dental experiences, practices, and...

Hassenford, R., 1958: Historical recollection of the origin, creation and introduction into service of military sanitary aviation in France. La Medecine Aeronautique 13(1): 83-98 Contd

Rose, H.; Riessbeck, K.H., 1977: Present tasks and aims of practice-related cancer research. Radiobiologia, Radiotherapia 18(2): 127-130

Valdez-Taubas, J.; Harispe, L.; Scazzocchio, C.; Gorfinkiel, L.; Rosa, A.L., 2003: Ammonium-induced internalisation of UapC, the general purine permease from Aspergillus nidulans. The Aspergillus nidulans UapC protein is a high-affinity, moderate-capacity, uric acid-xanthine transporter, which also displays a low transport capacity for hypoxanthine, adenine, and guanine. It has been previously shown that a functional UapC-G...

Christner, D.F.; Lakshman, M.K.; Sayer, J.M.; Jerina, D.M.; Dipple, A., 1994: Primer extension by various polymerases using oligonucleotide templates containing stereoisomeric benzo[a]pyrene-deoxyadenosine adducts. Four isomeric benzo[a]pyrene-deoxyadenosine adducts, corresponding to the products of trans opening of the epoxide ring in the four configurationally isomeric benzo[a]pyrene dihydrodiol epoxides by the amino group of deoxyadenosine, were separatel...

Hardcastle, J.; Carstairs, J.W.M.; Bax, N.D.S., 1993: Examination of 5-HT-3 receptor involvement in 5-HT-induced chloride secretion by rat intestine in vitro. Journal of Physiology (Cambridge) 467(0): 223P

Huffman, R., 1996: The beet armyworm in Texas and Oklahoma 1995. Widespread outbreaks of Spodoptera exigua on cotton in Texas occurred in 1995, with adverse dry weather, high aphid populations, cabbage looper [Trichoplusia ni] and other insect damage. The amount of damage caused by S. exigua varied widely from...