geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The impact of budesonide and other inhaled corticosteroid therapies in the management of asthma in children and adults


, : The impact of budesonide and other inhaled corticosteroid therapies in the management of asthma in children and adults. Clinical Therapeutics 25 Suppl C: C2-C14

Background: Since the recognition that asthma is characterized by extensive inflammation of the airways, the use of inhaled corticosteroids (ICSs) as controller therapy has become central to successful disease management. As the prevalence of asthma increases worldwide, there is concern about increasing numbers of patients with untreated or undertreated asthma, which may lead to deterioration in disease control, with direct effects on morbidity and mortality rates. The costs attributed to asthma translate into a considerable economic burden, from the direct costs of medical treatment to the costs incurred through lost work or school days. International treatment guidelines currently recommend early intervention with ICS therapy to improve lung function and disease control. Objective: This article reviews the role of therapy with ICSs, particularly budesonide, in improving the management of asthma in patients of all ages and in reducing the economic and social burdens of this disease. Results: Randomized, controlled clinical studies confirm the efficacy of early intervention with ICSs in patients with mild persistent asthma. Regular use of an ICS can reduce the number of exacerbations and hospitalizations in patients of all ages and with all disease severities. Conclusions: Budesonide has a well-established efficacy and safety profile. Its once-daily dosing may contribute to improved adherence and cost-effectiveness.

US$19.90

PMID: 14642800

DOI: 10.1016/s0149-2918(03)80302-8


Other references

Katsoulis, S.; Conlon, J.M., 1989: Calcitonin gene-related peptides relax guinea pig and rat gastric smooth muscle. Rat and human alpha- and beta-calcitonin gene-related peptide (CGRP), in the concentration range 1-100 nM, produced sustained relaxations of longitudinal muscle from the rat fundus and guinea pig gastric corpus. The peptides were equipotent and eq...

Weaver Charles Edward, 1953: Mineralogy and petrology of some Ordovician K-bentonites and related limestones. Geological Society of America Bulletin 64(8): 921-943

Lages, M.Carolina.Afonso.; Beilharz, K.; Morales Angeles, D.; Veening, J-Willem.; Scheffers, D-Jan., 2014: The localization of key Bacillus subtilis penicillin binding proteins during cell growth is determined by substrate availability. The shape of bacteria is maintained by the cell wall. The main component of the cell wall is peptidoglycan (PG) which is synthesized by Penicillin Binding Proteins (PBPs). The correct positioning of PBPs is essential for the maintenance of cell sh...

Prochazka, B.; Svoboda, J., 1977: Effect of the working regime of the reel on grain losses when cutting cereals. When cutting winter wheat and spring barley, grain losses and damage were lowest with a peripheral speed of the reel of 1.5-2.7 and 1.5-3.2 m/s, resp., with the ratio of reel speed:forward travel speed of 1.4-1.6 and 1.6-1.8, resp. Losses were low...

Singh, A.D.; Shields, J.A.; Eagle, R.C.; Shields, C.L.; Marmor, M.; D.P.tter, P., 1994: Iris melanoma in a ten-year-old boy with familial atypical mole-melanoma (FAM-M) syndrome. A ten-year-old boy was referred with an enlarging amelanotic iris tumor and secondary glaucoma in the left eye. After excisional biopsy it proved histopathologically to be an iris melanoma. The patient also had multiple nevi on his trunk, scalp, a...

Zuckier, L.S.; Dohan, O.; Li, Y.; Chang, C.Jen.; Carrasco, N.; Dadachova, E.; Dohan, O., 2004: Kinetics of perrhenate uptake and comparative biodistribution of perrhenate, pertechnetate, and iodide by NaI symporter-expressing tissues in vivo. Pertechnetate (as 99mTcO4-), 123I-, and 131I- have a long and successful history of use in the diagnosis and therapy of thyroid cancer, with uptake into thyroid tissue mediated by the sodium-iodide symporter (NIS). NIS has also emerged as a potent...

Petit, C.J.; Justino, H.; Ing, F.F., 2014: Melody valve implantation in the pulmonary and tricuspid position. Percutaneous implantation of valved stents is now routinely performed to treat pulmonary valve regurgitation and stenosis. In addition, there are isolated reports of implantation of valved stents in the tricuspid position to treat prosthetic tricu...

Pol, S.; Romeo, R.; Zins, B.; Driss, F.; Lebkiri, B.; Carnot, F.; Berthelot, P.; Bréchot, C., 1993: Hepatitis C virus RNA in anti-HCV positive hemodialyzed patients: significance and therapeutic implications. About 25% of French hemodialysis patients have antibodies against the hepatitis C virus (HCV), which may reflect either past or active HCV infection. It is important to evaluate the significance of these antibodies, as most hemodialysis patients a...

Sánchez Marugán, B.; Acebes García, M.; García Hinojosa, J.; León Cabello, M.J.; Casal Valiño, M., 2016: Iris mammillations. Three case reports. We report the cases of 3 young patients who were seen in our hospital with the diagnosis of iris mammillations. Two of them were bilateral without familial association. The third child had iris mammillations as part of an ocular melanocytosis. Non...

Nicolas P.; Fauvelle F.; Ennach A.; Petitjean O., 1986: Clinical evaluation of an original determination method of sulpiride using ion pair chromatography. Journal de Pharmacologie (Paris) 17(3): 474