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The impact of calcimimetics on mineral metabolism and secondary hyperparathyroidism in end-stage renal disease


, : The impact of calcimimetics on mineral metabolism and secondary hyperparathyroidism in end-stage renal disease. Kidney International. Supplement: S131-S136

The impact of calcimimetics on mineral metabolism and secondary hyperparathyroidism in end-stage renal disease. Secondary hyperparathyroidism is often complicated by elevations in calcium and phosphorus either as a result of the disease per se or due to toxicity from current therapeutic options. These disturbances in mineral metabolism limit the successfulness of therapy and have been implicated as contributing to the development and progression of vascular calcification, an important and often overlooked component of cardiovascular disease in patients on dialysis. Phosphorus, active vitamin D, and calcium all play important roles in the pathogenesis of secondary hyperparathyroidism; however, serum calcium is the primary regulator of minute-to-minute parathyroid hormone secretion. Small changes in serum calcium are detected by a cell surface calcium sensing receptor that has recently been cloned. Calcimimetic agents modulate the activity of the calcium-sensing receptor and result in profound reductions in levels of circulating parathyroid hormone. Additionally, these agents result in decreases in serum calcium, phosphorus, and calcium-phosphorus product. Recently completed phase 2 clinical trials with the second-generation calcimimetic agent cinacalcet HCl confirm that this agent represents a safe and effective novel therapeutic agent which has the potential to dramatically alter the treatment and complications associated with secondary hyperparathyroidism in patients on dialysis.

US$19.90

PMID: 14531786

DOI: 10.1046/j.1523-1755.64.s87.20.x


Other references

Löthgren, M.; Zethraeus, N., 2000: Definition, interpretation and calculation of cost-effectiveness acceptability curves. This paper discusses the definition, interpretation and computation of cost-effectiveness (CE) acceptability curves. A formal definition of the CE acceptability curve based on the net benefit approach is provided. The curve can be computed using p...

Saraux, H.; L.B.snerais, Y.; Graveleau, D.; Janet, L.G.; Chatellier, P., 1967: atypical forms of Bonnet-Dechaume-Blanc syndrome. Bulletins et Memoires de la Societe Francaise D'ophtalmologie 80: 326-333

Viville, C.; Meyer, P., 1972: Bladder diverticula in children, without cervico-urethral obstruction. Annales de Chirurgie Infantile 13(3): 201-208

Manstein, C.H.; Gottlieb, N.; Manstein, M.E.; Manstein, G., 2000: Giant basal cell carcinoma: a series of seven T3 tumors without metastasis. Plastic and Reconstructive Surgery 106(3): 653-656

Canale, M.; Cavera, A.L., 1966: Immuno-electrophoretic analysis of mammary secretion before and after delivery. Immunoelectrophoretic analysis for albumin, cerulo-plasmin, haptoglobin, transferrin, beta 1, gamma -M and gamma -A globulins, alpha -glycoprotein and beta -lipoprotein was carried out on human mammary secretion from up to 15 days before parturiti...

Baker M.; Brake J.; Mcdaniel G.R., 1981: The relationship between body weight loss during a forced molt and post molt reproductive performance of caged layers. Poultry Science 60(7): 1594

Plank, H.K., 1939: Peregrinator biannulipes Montr., a Predator of the Bamboo Powder-post Beetle in Porto Rico. Numerous nymphs of a small bug found in association with Dinoderus minutus, F., infesting bamboos stored in a shed in Porto Rico in the autumn of 1936, and some of which were seen to attack the beetles, were reared to the adult stage on D. minutus...

Tuomisto J.; Walaszek E.J.; Smissman E.E.; Pazdernik T.L., 1974: Decalin analogs of phenethylamines as inhibitors of amine uptake by rabbit platelets part 2 uptake of 5 hydroxy tryptamine. Journal of Pharmaceutical Sciences 63(11): 1714-1718

Mueller, U.; Graeber, M.B.; Haberhausen, G.; Koehler, A., 1994: Molecular basis and diagnosis of neurogenetic disorders. Over the past few years, molecular neurogenetics has developed into one of the most promising and active research fields. The new discipline applies modern molecular genetic techniques to the investigation of classical neurological disorders. In t...

Chen ShouYi; Y.X.nBing; X.J.n et al., 2003: Construction and identification of a cDNA expression library from Clonorchis sinensis. In this study, a cDNA expression library for C. sinensis was constructed. Initially, total RNA from the helminth was extracted and cDNA was synthesized by SMART cDNA library protocol. The products were then digested and fractionated. The cDNA with...