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The impact of chromatin organization of vitamin D target genes

, : The impact of chromatin organization of vitamin D target genes. Anticancer Research 26(4a): 2637-2645

The vitamin D receptor (YDR), the nuclear receptor for 1a,25-dihydroxyvitamin D3 (1a,25(OH)(2)D-3), controls gene expression by binding discrete DNA sequences in promoter regions of target genes, referred to as 1a,25(OH)(2)D-3 response elements (VDREs). Although these elements are well characterized in vitro, the function of VDREs in living cells in the context of chromatin is still largely unknown.


PMID: 16886674

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