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The impact of cross-immunity, mutation and stochastic extinction on pathogen diversity


, : The impact of cross-immunity, mutation and stochastic extinction on pathogen diversity. Proceedings. Biological Sciences 271(1556): 2431-2438

We examine the dynamics of antigenically diverse infectious agents using a mathematical model describing the transmission dynamics of arbitrary numbers of pathogen strains, interacting via cross-immunity, and in the presence of mutations generating new strains and stochastic extinctions of existing ones. Equilibrium dynamics fall into three classes depending on cross-immunity, transmissibility and host population size: systems where global extinction is likely, stable single-strain persistence, and multiple-strain persistence with stable diversity. Where multi-strain dynamics are stable, a diversity threshold region separates a low-prevalence, low-diversity region of parameter space from a high-diversity, high-prevalence region. The location of the threshold region is determined by the reproduction number of the pathogen and the intensity of crossimmunity, with the sharpness of the transition being determined by the manner in which immunity accrues with repeated infections. Host population size and cross-immunity are found to be the most decisive factors in deter-mining pathogen diversity. While the model framework developed is simplified, we show that it can capture essential aspects of the complex evolutionary dynamics of pathogens such as influenza.

US$19.90

PMID: 15590592

DOI: 10.1098/rspb.2004.2877


Other references

Rockwood, C.A.; O'donoghue, D.H., 1960: The surgical mask: its development, usage, and efficiency. A review of the literature, and new experimental studies. Archives of Surgery 80: 963-971

Devereux, W.P., 1963: Endometriosis: Long-Term Observation, With Particular Reference To Incidence Of Pregnancy. Obstetrics and Gynecology 22: 444-450

Martínez, F.; Martín Luengo, F.; Valdés, M., 1993: Treatment with vancomycin of experimental endocarditis caused by Streptococcus sanguis II resistant to penicillin. Streptococcus viridans continues to be the most frequent causal agent of infective endocarditis. Treatment has become more complicated due to the increase in resistance to penicillin and cephalosporins. In order to study the possible efficacy of v...

Koike, M.; Shah, P.C.; Reed, L.J., 1960: alpha-Keto acid dehydrogenation complexes. III. Purification and properties of dihydrolipoic dehydrogenase of Escherichia coli. Journal of Biological Chemistry 235: 1939-1943

Takahashi, S.; Yoshimura, Y.; Yamamoto, T.; Wakita, M., 2008: Cellular expression of Bcl-2 and Bax in atrophic submandibular glands of rats. In submandibular gland atrophy, most acinar cells disappear by apoptosis, while many duct cells remain. The present study aimed to establish whether Bcl-2 and Bax, members of the Bcl-2 gene family, regulating the signalling pathway of apoptosis we...

Roy, S.B.; Bhatia, M.L.; Guleria, J.S.; Ahuja, M.M., 1961: Percutaneous retrograde arterial catheterization of the left ventricle (and atrium) in hundred thirty-one persons. Indian Heart Journal 13: 100-106

Miles, H.T.; Lewis, T.P.; Becker, E.D.; Frazier, J., 1973: Identification of the amide II band in the cis-amide 1-methyluracil, in poly(U), and in poly(A)-poly(U). Journal of Biological Chemistry 248(3): 1115-1117

Vessman J.; Hartvig P., 1972: Gas chromatography and electron capture detection of benzophenones part 8 study of the sensitivity in pulsed and direct current mode nickel 63 high temperature detectors. Acta Pharmaceutica Suecica 9(5): 463-474

Nazaretyan E.E.; Gulyan E.A., 1983: Adenosine metabolism in leukocytes in periodic disease. The change of adenosine deaminase [ADA], 5'-nucleotidase and AMP deaminase activity in the blood of patients with periodic disease was investigated. In patients with this disease increase of the activity of 5'-nucleotidase and decrease o...

Lewis, M.A.; Medici, A.C., 1995: Private payers of health care in Brazil: characteristics, costs and coverage. The private sector is the predominant provider of health care in Brazil, particularly for inpatient services, and financing is a mix of public (through a prospective reimbursement system) and private. Roughly a quarter of the population has privat...