+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The impact of cyclosporine on the development of immunosuppressive therapy--pediatric transplantation using cyclosporine

, : The impact of cyclosporine on the development of immunosuppressive therapy--pediatric transplantation using cyclosporine. Transplantation Proceedings 36(2 Suppl): 197s-202s

Cyclosporine A (CsA) was introduced to pediatric renal transplantation more than 20 years ago, and it has greatly improved graft survival and made transplantation the treatment of choice for children with end-stage renal failure. Exposure to CsA was shown to be highly variable among transplant recipients. Therefore, major efforts have been employed to monitor CsA blood levels. The widely used trough levels had never been formally validated, and every center had defined its own target values. With the advanced microemulsion formula of CsA, drug exposure became more predictable, but scientifically evaluated monitoring concepts are still lacking. Monitoring the absorption phase using single time points (eg, 2 hours after ingestion) is promising, as shown in adult trials. In pediatric transplant recipients, randomized clinical trials have to be implemented urgently to fully exploit the potential of CsA in the prevention of graft rejection while minimizing toxicity. Although newer immunosuppressive drugs have been developed, further studies should be undertaken to define the role of CsA in combination protocols.


PMID: 15041336

DOI: 10.1016/j.transproceed.2004.01.051

Other references

Liss R.H.; Cotton F.A.; Kensler C.J., 1969: Inst whole body radioautographic localization and semiquantitative determination of chemo therapeutic agents in normal and neopl tumor bearing rodents. Toxicology & Applied Pharmacology 14(3): 615

Nasioudis, D.; Ramer, I.; Sisti, G.; Fambrini, M., 2016: Risk of Second Primary Tumors After Childhood and Adolescent Ovarian Malignancies: A SEER Analysis (1973-2011). To calculate the incidence of second primary tumors (SPTs) in patients previously diagnosed with malignant ovarian tumors in childhood and adolescence. This is an area of interest given the high survival rate and, thus, the long disease-free perio...

Bodmer, R.; Carretto, R.; Jan, Y.N., 1989: Neurogenesis of the peripheral nervous system in Drosophila embryos: DNA replication patterns and cell lineages. Cell lineages that give rise to the PNS were studied using the thymidine analog 5-bromo-2'-deoxyuridine (BrdU) to visualized DNA replication immunocytochemically. The precursors of the PNS in the body segments of Drosophila embryos replicate...

Aizu, S., 1982: A comparison of excitatory and inhibitory neuromuscular junctions in insect. Unknown

Duckett, C.S.; Perkins, N.D.; Leung, K., 1995: Cytokine induction of nuclear factor kB in cycling and growth-arrested cells. Evidence for cell cycle-independent activation. The Journal of Biological Chemistry 270: 836-40

Hu, K.; Gaudron, P.; Anders, H.J.; Ertl, G., 1993: Chronic effect of very early ACE-inhibitor treatment on hemodynamics and remodeling in rats after myocardial infarction. European Heart Journal 14(ABSTR SUPPL ): 359

Sparrowe, Rollin D., 2002: Welcome and opening statement. Rahm, Jennifer [Editor] Transactions of the North American Wildlife and Natural Resources Conference Volume 67 : 1-8

Sassi, M.G.; Hoitink, A.J.F.; Vermeulen, B.; Hidayat, H., 2013: Sediment discharge division at two tidally influenced river bifurcations. In response to mean flow and secondary circulation by employing a boat-mounted acoustic Doppler current profiler (ADCP), to survey transects at bifurcating branches during a semidiurnal tidal cycle. The ADCP collecting flow velocity and acoustical...

Caviston, Ruth V., 1952: The oldest fruit industry the fig. History of the industry, with particular reference to its beginnings in California.

Mansoor Montazeri, 1993: Evaluation of a few wheat selective grass herbicides at two times of application on canary grass (Phalaris minor) and wild oat (Avena sterilis). Trials were conducted in a wheat cv. Flat field at Gorgan in 1992 to evaluate the effects of fenoxaprop-P (at 0.55 and 0.69 kg/ha), diclofop-methyl (at 0.9 kg) and tralkoxydim (at 0.36 kg) on canary grass and wild oats at Zadoks' stages 21 an...