geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The impact of geometric uncertainty on hypofractionated external beam radiation therapy of prostate cancer


, : The impact of geometric uncertainty on hypofractionated external beam radiation therapy of prostate cancer. International Journal of Radiation Oncology, Biology, Physics 57(3): 833-842

Purpose: Recent publications indicate alpha/beta for prostate carcinoma could be lower than assumed. Therefore, hypofractionation might increase the therapeutic ratio. However, patient repositioning and organ motion may affect hypofractionated treatments more than conventional treatments. Our purpose is to evaluate the potential impact of geometric uncertainties on hypofractionated treatments. Methods and Materials: Tumor control probability (TCP) and normal tissue complication probability (NTCP) are calculated for simulated conventional and hypofractionated treatments, assuming alpha/beta of 1.5 Gy for prostate and 3.0 Gy for rectum. A Monte Carlo simulation randomly samples systematic and random displacements and produces the cumulative dose distribution for the prostate and rectum. The limiting number of fractions and the impact of different alpha/beta values are also explored. Results: A consistent but small reduction in TCP is seen with hypofractionation (generally <1%) as a result of geometric uncertainties. Escalated hypofractionation seems to allow large TCP gains (apprx20%) without increasing NTCP. Treatments of five fractions seem to affect outcome minimally. The alpha/beta value has a much greater impact on TCP than geometric uncertainties. Conclusions: The potential increased influence of geometric uncertainties on hypofractionation seems small. Limited knowledge of radiobiologic response is likely a greater obstacle to prostate hypofractionation than geometric uncertainties.

US$19.90

PMID: 14529791

DOI: 10.1016/s0360-3016(03)00638-2


Other references

Silvennoinen-Kassinen, S., 1986: Immunological laboratory studies in neurological diagnosis. Duodecim; Laaketieteellinen Aikakauskirja 102(5): 300-305

Franco Junior J.G.; Mauri A.L.; Baruffi R.; Cornicelli J.; Camargo C.; Ursolino G.L., 1991: General rules of an in vitro fertilization and human embryos transfer program. The success of an in-vitro fertilization and human embryos transfer program (IVF-ET) may depend on several variables. This paper describes both clinical and laboratory general rules which are almost always excluded from the papers dealing with thi...

Pain C.F.; Wilford J.R.; Dohrenwend J.C., 1997: Regolith of Cape York Peninsula. AGSO Bulletin Pages 419-428

Gedzelman, E.R.; Meador, K.J., 2013: Neurological and psychiatric sequelae of developmental exposure to antiepileptic drugs. The neurons in the developing mammalian brain are susceptible to antiepileptic drug (AED) effects. It is known that later in life deficits in cognitive performance as well as psychiatric deficits can manifest after early AED exposure. The extent o...

Giardino, N.D.; Curtis, J.L.; Andrei, A-Cristian.; Fan, V.S.; Benditt, J.O.; Lyubkin, M.; Naunheim, K.; Criner, G.; Make, B.; Wise, R.A.; Murray, S.K.; Fishman, A.P.; Sciurba, F.C.; Liberzon, I.; Martinez, F.J.; Fishman, A.P.; Bozzarello, B.Ann.; Al-Amin, A.; Katz, M.; Wheeler, C.; Baker, E.; Barnard, P.; Cagle, P.; Carter, J.; Chatziioannou, S.; Conejo-Gonzales, K.; Dubose, K.; Haddad, J.; Hicks, D.; Kleiman, N.; Milburn-Barnes, M.; Nguyen, C.; Reardon, M.; Reeves-Viets, J.; Sax, S.; Sharafkhan, 2010: Anxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional study. Anxiety in patients with chronic obstructive pulmonary disease (COPD) is associated with self-reported disability. The purpose of this study is to determine whether there is an association between anxiety and functional measures, quality of life a...

Wang XiaoXue; M.L.Geng, 2007: Polycomb-group (Pc-G) proteins control seed development in Arabidopsis thaliana L. Polycomb-group (Pc-G) proteins repress their target gene expression by assemble complexes in Drosophila and mammals. Three groups of Pc-G genes, controlling seed development, flower development and vernalization response, have been identified in...

Collins, T.; Baker, R.L.; Wilhelm, J.M.; Olmsted, J.B., 1980: A cortical scaffold in the ciliate Tetrahymena. Journal of Ultrastructure Research 70(1): 92-103

Friedman; Guo; Lubell; Frankel, 1992: Reexamination of tests of the Wannier threshold law for two-electron escape. Physical Review. A, Atomic, Molecular, and Optical Physics 46(1): 652-655

Guerlac, H.; Newton, I., 1983: Theological voluntarism and biological analogies in Newton's physical thought. Journal of the History of Ideas 44(2): 219-229

Wang, Y.; Wilson, F.A.; Stimpson, J.P.; Wang, H.; Palm, D.W.; Chen, B.; Chen, L-Wu., 2017: Fewer immigrants have preventable emergency department visits in the United States. The aim of this study is to examine differences in having preventable emergency department (ED) visits between noncitizens, naturalized and US-born citizens in the United States. We linked the 2008-2012 Medical Expenditure Panel Survey with Nation...