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The naturally trans-acting ribozyme RNase P RNA has leadzyme properties

, : The naturally trans-acting ribozyme RNase P RNA has leadzyme properties. Nucleic Acids Research 33(21): 6920-6930

Divalent metal ions promote hydrolysis of RNA backbones generating 5'OH and 2';3'P as cleavage products. In these reactions, the neighboring 2'OH act as the nucleophile. RNA catalyzed reactions also require divalent metal ions and a number of different metal ions function in RNA mediated cleavage of RNA. In one case, the LZV leadzyme, it was shown that this catalytic RNA requires lead for catalysis.


PMID: 16332695

DOI: 10.1093/nar/gki993

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