+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The pathophysiology of chronic graft-versus-host disease

, : The pathophysiology of chronic graft-versus-host disease. International Journal of Hematology 79(3): 209-215

Chronic graft-versus-host disease (GVHD) still remains the most significant complication after allogeneic hematopoietic stem cell transplantation. The disease usually appears after day 100 and is characterized by signs and symptoms similar to autoimmune diseases. The pathophysiology of chronic GVHD is poorly understood because of the lack of highly satisfactory animal models and basic studies in patients. It has not been clearly determined whether the disease is a distinct entity or a continuation of acute GVHD. In experimental and clinical studies of chronic GVHD, thymic atrophy, lymphocyte depletion, and autoantibody formation have been described. Conditioning regimens and acute GVHD may disrupt thymic function and dysregulate the negative selection process of potentially autoreactive T-lymphocytes. Disruption of thymic apoptosis and failure to eliminate the majority of self-reactive lymphocytes may lead to impairment of lymphocyte homeostasis and self tolerance. Expansion and effector functions of autoreactive T-cells will then promote autoreactive B-cell activation and production of autoantibodies with target-organ damage. Chronic GVHD requires continuous CD4+ T-cell help for B-cells and is known as T-helper 2 (Th2) disease. Murine models have demonstrated the roles of interleukin (IL)-12 and IL-18 in chronic GVHD. IL-12 may cause an increase in donor CD8+ cytotoxic T-cells leading to conversion of chronic GVHD to an acute form. In contrast, IL-18 prevents chronic GVHD by decreasing numbers of CD4+ (Th2) cells and host-reactive B-cell activation and reducing alloantigen-specific immune response. Mouse and human cellular genomics coupled with advances in cell biology in donor-recipient tolerance will improve our understanding of transplantation immunology and may offer new approaches to the challenge of ameliorating chronic GVHD. Copyright 2004 The Japanese Society of Hematology.


PMID: 15168586

DOI: 10.1532/IJH97.04015

Other references

Gagnon-Girouard, M-Pierre.; Bégin, C.; Provencher, Véronique.; Tremblay, A.; Boivin, S.; Lemieux, S., 2011: Subtyping weight-preoccupied overweight/obese women along restraint and negative affect. Previous clustering analysis performed among samples of bulimic or binge eating women have consistently yielded two subtypes (Dietary and Dietary-Depressive). The present study verifies whether this clustering solution could be replicated among we...

Bruun, L.S.; Elkjaer, S.; Bitsch-Larsen, D.; Andersen, O., 2001: Hepatic failure in a child after acetaminophen and sevoflurane exposure. Anesthesia and Analgesia 92(6): 1446-1448

Yeung, C.; Lee, T.N., 2002: Larval transport and retention of the spiny lobster, Panulirus argus, in the coastal zone of the Florida Keys, USA. The spiny lobster Panulirus argus is of ecological and commercial importance in the South Florida coast of the continental USA and throughout the Intra-Americas Sea. Essential spiny lobster habitat in South Florida is primarily located in the Flor...

Ren, J-Ma.; Zhao, Y-Rong.; Huang, W-Li.; Zhang, J.; Shen, T.; Xie, X.; Cai, J.; Yang, L.; Cehn, F.; Zeng, G., 2007: Study on clustering of Yunnan unexplained sudden death in household and village. Objective To discuss the clustering of Yunnan unexplained sudden death(YUSD) in household and village Methods Fifty-two cases were found by YUSD surveillance system in 2005. Poisson distribution and beta-binomial distribution (BBD) were employed...

Chedid L., 1988: Ganglioside gm2 bearing tumor cells targeted with clostridium perfringens delta toxin. Proceedings Of The American Association For Cancer Research Annual Meeting: 2

Zhang, Z-mei.; Gu, P.; Yi, X-hua.; Fang, X.; Zeng, Y.; Zhang, S-xia.; Zhu, X-you.; Zhang, Y-dong.; Gu, J.; Qiu, W-zhe.; Zhang, L., 2014: Effects of 1, 25 (OH)2D3 on bleomycin-induced pulmonary fibrosis in mice. To observe the effects of 1, 25(OH)2D3 on bleomycin-induced pulmonary fibrosis in mice and to explore its mechanisms. Ninety male C57BL/6 mice, 6 to 8 weeks old, were randomly divided into 3 groups according to the table of random numbers: a contr...

Singh, R.P.; Jayan, P.K.; Singh, R.A., 1996: Effect of location, date of seeding, phosphorus and potash on seed yield of Stylosanthes hamata cv. Verano. Higher average seed production (873 kg/ha) was obtained at Dharwad, Karnataka, India and lower seed production (387 kg) at Jhansi, Uttar Pradesh, both with optimum sowing on 30 June; seed yield decreased with the delay in sowing. Increased seed yi...

Anonymous, 1998: Practical procedures for nurses. 7.1. Urine testing--1--Observation. Nursing Times 94(4): Suppl 1-2

Giesbrecht, F.G.; Nordskog, A.W., 1963: Estimating age at sexual maturity from flock records. Several measures of age at sexual maturity of pullets from flock production records were compared. The study was based on data from the 1959 and 1960 Iowa Multiple Unit Poultry Test. Variance components for strains, farms, strain x farm interactio...

Roig, J.C.; Knight, M.; Neu, J., 1993: Is a lumbar puncture necessary in the evaluation of neonatal sepsis?. Pediatric Research 33(4 PART 2): 233A