geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Transgenic mouse model for breast cancer: induction of breast cancer in novel oncogene HCCR-2 transgenic mice


, : Transgenic mouse model for breast cancer: induction of breast cancer in novel oncogene HCCR-2 transgenic mice. Oncogene 23(10): 1950-1953

Transgenic mice containing novel oncogene HCCR-2 were generated to analyse the phenotype and to characterize the role of HCCR-2 in cellular events. Mice transgenic for HCCR-2 developed breast cancers and metastasis. The level of p53 in HCCR-2 transgenic mice was elevated in most tissues including breast, brain, heart, lung, liver, stomach, kidney, spleen, and lymph node. We examined whether stabilized p53 is functional in HCCR-2 transgenic mice. Defective induction of p53 responsive genes including p21WAF1, MDM2, and bax indicates that stabilized p53 in HCCR-2 transgenic mice exists in an inactive form. These results suggest that HCCR-2 represents an oncoprotein that is related to breast cancer development and regulation of the p53 tumor suppressor.

US$19.90

PMID: 14691448

DOI: 10.1038/sj.onc.1207356


Other references

Shami Y., 1986: Multiple vessel specimen tray with lid for releasably adhering vessel covers us patent 4599314 july 8 1986. Official Gazette Of The United States Patent & Trademark Office Patents2: 779

Ciesielski, T., 1885: Bartnictwo czyli hodowla pszozol Die Zeidelei oder die Bienenzucht. Unknown

Richardson, A.D.; Carbone, M.S.; Keenan, T.F.; Czimczik, C.I.; Hollinger, D.Y.; Murakami, P.; Schaberg, P.G.; Xu, X., 2013: Seasonal dynamics and age of stemwood nonstructural carbohydrates in temperate forest trees. Nonstructural carbohydrate reserves support tree metabolism and growth when current photosynthates are insufficient, offering resilience in times of stress. We monitored stemwood nonstructural carbohydrate (starch and sugars) concentrations of the...

Yuan, R.; Fan, S.; Achary, M.; Stewart, D.M.; Goldberg, I.D.; Rosen, E.M., 2001: Altered gene expression pattern in cultured human breast cancer cells treated with hepatocyte growth factor/scatter factor in the setting of DNA damage. The cytokine hepatocyte growth factor/scatter factor (HGF/SF) protects epithelial and cancer cells against DNA-damaging agents via a pathway involving signaling from c-Met fwdarw phosphatidylinositol-3-kinase fwdarw c-Akt. However, the downstream...

Ben-Yosef, N.; Wilner, K.; Abitbol, M., 1986: Radiance statistics vs ground resolution in infrared images of natural terrain. Applied Optics 25(16): 2648-2649

Wilberg, T.; Dammen, T.; Friis, S., 2000: Comparing Personality Diagnostic questionnaire-4+ with Longitudinal, Expert, All Data (LEAD) standard diagnoses in a sample with a high prevalence of axis I and axis II disorders. A comparison between the Personality Diagnostic Questionnaire-4+ (PDQ-4+) and Longitudinal, Expert, All Data (LEAD) standard diagnoses was made in a sample of 100 patients with a high prevalence of both axis I and axis II disorders. The internal c...

Ermishov, M.; Sukhanova, A.; Kryukov, E.; Grokhovsky, S.; Zhuze, A.; Oleinikov, V.; Jardillier, J.C.; Nabiev, I., 2000: Raman and surface-enhanced Raman scattering spectroscopy of bis-netropsins and their DNA complexes. The interactions of three bis-netropsins (bis-Nts), which are potent catalytic inhibitors of DNA-binding enzymes, with three double-stranded oligonucleotides (OLIGs), which contain sites of different specific affinities for each bis-Nt, were analy...

Counillon, L.; Scholz, W.; Lang, H.J.; Pouysségur, J., 1993: Pharmacological characterization of stably transfected Na+/H+ antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties. A fibroblast mutant cell line devoid of Na+/H+ exchange was used to stably express cDNAs encoding the NHE1, NHE2, and NHE3 Na+/H+ antiporters. Pharmacological studies using amiloride and two of its 5-N-substituted derivatives, 5-N-dimethyl amilori...

Robinson, N.A.; Flotte, C.T., 1974: Traumatic aneurysms of the carotid arteries. American Surgeon 40(2): 121-124

Jakovljevic, M.Michael.; Arsenijevic, J.; Pavlova, M.; Verhaeghe, N.; Laaser, U.; Groot, W., 2016: Within the triangle of healthcare legacies: comparing the performance of South-Eastern European health systems. Inter-regional comparison of health-reform outcomes in south-eastern Europe (SEE). Macro-indicators were obtained from the WHO Health for All Database. Inter-regional comparison among post-Semashko, former Yugoslavia, and prior-1989-free-market SE...