+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Treatment of functional dyspepsia with a herbal preparation. A double-blind, randomized, placebo-controlled, multicenter trial

, : Treatment of functional dyspepsia with a herbal preparation. A double-blind, randomized, placebo-controlled, multicenter trial. Digestion 69(1): 45-52

Background: We aimed to assess the efficacy and safety of a herbal preparation STW 5-II containing extracts from bitter candy tuft, matricaria flower, peppermint leaves, caraway, licorice root and lemon balm for the treatment of patients with functional dyspepsia. Methods: 120 patients with functional dyspepsia were randomly assigned to 1 of 4 treatment groups. Each patient received the treatment for three consecutive 4-week treatment blocks. The first two treatment blocks were fixed. For the third treatment period, medication was based upon the investigator's judgement of symptom improvement during the preceding treatment period. In patients without adequate control of symptoms, the treatment was switched, or if symptoms were controlled, the treatment was continued. The primary outcome measure was the improvement of a standardized gastrointestinal symptom score (GIS). Findings: During the first 4 weeks, the GIS significantly decreased in subjects on active treatment compared to the placebo (p < 0.001). During the second 4-week period, symptoms further improved in subjects who continued on active treatment or who switched to the active treatment (p < 0.001), while symptoms deteriorated in subjects who switched to placebo. After 8 weeks 43.3% on active treatment and 3.3% on placebo reported complete relief of symptoms. (p < 0.001 vs. placebo). Conclusion: In patients with functional dyspepsia, the herbal preparation tested improved dyspeptic symptoms significantly better than placebo.


PMID: 14755152

DOI: 10.1159/000076546

Other references

Couvreur,, B., 1984: Are growth substances an indispensable link to managing crops?. Perspectives agricoles: (79) 60-66

Su, Y.; Deng, G.; Gai, Y.; Li, Y.; Gao, Y.; Du, J.; Geng, Y.; Chen, Q.; Qiao, W., 2010: Comparative functional analysis of Jembrana disease virus Tat protein on lentivirus long terminal repeat promoters: evidence for flexibility at its N-terminus. Jembrana disease virus (JDV) encodes a potent regulatory protein Tat that strongly stimulates viral expression by transactivating the long terminal repeat (LTR) promoter. JDV Tat (jTat) promotes the transcription from its own LTR as well as non-co...

Lyon, P.F.; Beffa, T.; Blanc, M.; Auling, G.; Aragno, M., 2000: Isolation and characterization of highly thermophilic xylanolytic Thermus thermophilus strains from hot composts. This is the first detailed report of xylanolytic activity in Thermus strains. Two highly thermophilic xylanolytic bacteria, very closely related to non-xylanolytic T. thermophilus strains, have been isolated from the hottest zones of compost piles...

Hagn C.; Lassmann H.; Fischer Colbrie R.; Winkler H., 1985: Chromogranin a and b in adrenal medulla neuronal and endocrine tissues. Journal of Neurochemistry 44(SUPPL): S161

Stringfellow, J.; Shipman, R., 1981: Deer feeding preferences on planted hardwood seedlings Odocoileus virginianus, Pennsylvania. Research briefs Pennsylvania Agricultural Experiment Stationer Fall 14(2): 22-24

Smith, P.A.; Sheely, M.V.; Hakspiel, S.J.; Miller, S., 2003: Volatile organic compounds produced during irradiation of mail. In 2001, Bacillus anthracis spores were delivered through the United States postal system in a series of bioterrorist acts. Controls proposed for this threat included sanitization with high-energy electrons. Solid phase microextraction was used wi...

Fruget, J.F.; Dessaix, J., 2002: Biodiversite structurelle et fonctionnelle des peuplements de macroinvertebres en tant que descripteur de la variabilite hydraulique: Exemple de deux parties court-circuitees du Rhone Moyen. The aquatic communities of a hydrosystem are constantly subject to the space-time variability of the environment. As a result, the dominant species are those presenting the biological characteristics and the ecological preferences best adapted wit...

Ghoorchi, T.; Rahimi, S.; Rezaeian, M.; Ghorbani, G.R., 2003: Degradation of dry matter and fiber of five feeds by rumen anaerobic fungi of sheep. An experiment was carried out to estimate the potential activity of rumen anaerobic fungi in the degradation of dry matter and fibre of feeds. Samples of wheat bran, bagasse, cotton seed, alfalfa and corn silage were used as the substrates to cult...

Anonymous, 1989: Products & materials. Science 245(4915): 318-318

Yakes, B.; Kelsey, K.T.; Seitz, T.; Hashimoto, D.; Feldman, H.A.; Christiani, D.C., 1991: Occupational skin disease in newspaper pressroom workers. Studies of printing industry tradespeople have reported an increased problem of dermatologic abnormalities, including contact dermatitis and dermatitis attributed to solvent exposure. The current cross-sectional health survey of dermatological con...