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Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin

, : Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin. New England Journal of Medicine 352(24): 2499-2507

BACKGROUND:Selective blockade of interactions between leukocytes and vascular endothelium in the gut is a promising strategy for the treatment of inflammatory bowel diseases.METHODS:We conducted a multicenter, double-blind, placebo-controlled trial of MLN02, a humanized antibody to the (alpha)(sub 4)(beta)(sub 7) integrin, in patients with active ulcerative colitis.


PMID: 15958805

DOI: 10.1056/NEJMoa042982

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