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Une etiologie d'hypothyroidie a ne pas meconnaitre : l'hypothyroidie centrale associee au traitement par bexarotene (Targretin((R)))

, : Une etiologie d'hypothyroidie a ne pas meconnaitre : l'hypothyroidie centrale associee au traitement par bexarotene (Targretin((R))). Annales de Biologie Clinique 64(4): 331-334

We report the case of a patient with cutaneous T-cell lymphoma treated by bexaroten (Targretin (R)), a synthetic retinoid analog with specific affinity for retinoid X receptor. The treatment induced mixed hyperlipidemia and severe central hypothyroidism characterized by reduced TSH and thyroxine serum levels. Only the pituitary thyreotrope function was affected. Targretin (R) therapy can be maintained.


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Nash, David, 1965: The expression of Hairless in Drosophila and the role of two closely linked modifers of opposite effect. The Hairless(H), Suppressor of Hairless(Su-H) and Enhancer of Hairless(E-H) mutants of Drosophila melanogaster were studied with respect to their phenotypic effects on bristles. Wide variation in the penetrance of Hairless was produced by artifici...

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