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Une etiologie d'hypothyroidie a ne pas meconnaitre : l'hypothyroidie centrale associee au traitement par bexarotene (Targretin((R)))


, : Une etiologie d'hypothyroidie a ne pas meconnaitre : l'hypothyroidie centrale associee au traitement par bexarotene (Targretin((R))). Annales de Biologie Clinique 64(4): 331-334

We report the case of a patient with cutaneous T-cell lymphoma treated by bexaroten (Targretin (R)), a synthetic retinoid analog with specific affinity for retinoid X receptor. The treatment induced mixed hyperlipidemia and severe central hypothyroidism characterized by reduced TSH and thyroxine serum levels. Only the pituitary thyreotrope function was affected. Targretin (R) therapy can be maintained.

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