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Xylylated dimers of putrescine and polyamines: influence of the polyamine backbone on spermidine transport inhibition

, : Xylylated dimers of putrescine and polyamines: influence of the polyamine backbone on spermidine transport inhibition. Bioorganic & Medicinal Chemistry Letters 13(19): 3267-3271

Dimeric norspermidine and spermidine derivatives are strong competitive inhibitors of polyamine transport. A xylyl tether was used for the dimerization of various triamines and spermine via a secondary amino group, and of putrescine via an ether or an amino group. Dimerization of putrescine moieties potentiates their ability to compete against spermidine transport to a much greater extent than for triamine dimers.


PMID: 12951106

DOI: 10.1016/s0960-894x(03)00668-1

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