geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A polymeric micelle MRI contrast agent with changeable relaxivity


, : A polymeric micelle MRI contrast agent with changeable relaxivity. Journal of Controlled Release 114(3): 325-333

Polymeric micelles were formed from cationic polymers (polyallylamine or protamine) and anionic block copolymers (poly(ethylene glycol)-b-poly(aspartic acid) derivative) that bound Gd ions providing high contrasts in Magnetic Resonance Imaging (MRI) by shortening the T(1) longitudinal relaxation time of protons of water. The Gd-binding block copolymer alone showed high relaxivity (T(1)-shortening ability) values from 10 to 11 mol(-1) s(-1), while the polymeric micelles exhibited low relaxivity values from 2.1 to 3.6 mol(-1) s(-1). These findings point to the feasibility of a novel MRI contrast agent that selectively provides high contrasts at solid tumor sites owing to a dissociation of the micelle structures, while selective delivery to the tumor sites is achieved in the polymeric micelle form.

US$19.90

PMID: 16891027

DOI: 10.1016/j.jconrel.2006.05.030


Other references

Brumfiel, G.; Knight, J., 2003: In the shadow of war. The conflict in Iraq and the terrorist threats during 2003 have affected science and scientists in many ways. The pressures placed on scientists by the conflict in Iraq and the ongoing war on terror were starkly illustrated by the suicide of U.K....

M.Z.iYong; Jian ZhongYou; Jiang Ping; Cai JiaLi; Zhang ZhenXing; Cai BaoXiang, 1997: A dot-ELISA for detection of antibodies to porcine reproductive and respiratory syndrome virus. A dot-ELISA was established for detecting antibodies to porcine reproductive and respiratory syndrome virus (PRRSV, American isolate). The assay was specific and did not react with sera positive for swine fever virus, Aujeszky's virus or swin...

D.Barbosa, N.C., 1953: New technic for flocculation micro-reaction in syphilis. Revista Brasileira de Medicina 10(12): 846-848

Choi, W-Jeong.; Cynn, H-Seock.; Lee, C-Hwi.; Jeon, H-Seon.; Lee, J-Hyun.; Jeong, H-Jung.; Yoon, T-Lim., 2015: Shrug exercises combined with shoulder abduction improve scapular upward rotator activity and scapular alignment in subjects with scapular downward rotation impairment. The aim of this research was to investigate which shoulder abduction angle (30°, 90°, 150°) during shrug exercise is superior for (1) activating the scapular upward rotators and (2) improving scapular and clavicular position in subjects with sc...

Matsuda, S.; Yoshimura, H.; Kondo, S.; Sano, K., 2017: Temporomandibular dislocation caused by pancreatic cancer metastasis: A case report. Metastasis-induced dislocation of the temporomandibular joint (TMJ) is rare. The present study describes a case of TMJ dislocation caused by metastasis from pancreatic cancer, and discusses this in the context of literature on occlusal abnormality...

Rosevear P.; Vanaken T.; Baxter J.; Ferguson Miller S., 1980: Alkyl glycoside detergents a simpler synthesis and their effects on kinetic and physical properties of cytochrome c oxidase. Octyl glucoside is an effective, nonionic, solubilizing agent for membrane proteins with the advantage of ease of removal by dialysis. In order to study the detergent-sensitive activity of cytochrome c oxidase, this detergent was chosen because of...

Chandrakant Nimgulkar, C.; Dattatray Patil, S.; Dinesh Kumar, B., 2011: Anti-asthmatic and anti-anaphylactic activities of Blatta orientalis mother tincture. (B. orientalis MT), a homeopathic medicine, in experimental animal models. The anti-asthmatic activity of B. orientalis MT was studied in the bronchial hyperactivity models, acetylcholine and histamine induced bronchospasm, in guinea pigs. Anti-an...

Scherer, K.; Bücheler, E.; Erbe, W., 1977: Diagnostic radiology for tumors for the small intestine(author's transl). The fractionated gastrointestinal tract presents technical problems which result in a large number of diagnostic errors in regard to tumors of the small intestine. Pharmacoradiologic processes and Sellink's sounding method deal successfully w...

Church, W.H.; Chiang, H.T., 1998: Characterization and quantification of organic anions with capillary zone electrophoresis using direct and indirect detection. A comparison of the separation and quantification capabilities of capillary zone electrophoresis (CZE) using direct and indirect detection of organic anions was conducted. A conventional CZE separation (normal polarity, electroosmotic flow toward...

Juffs, H.S.; Madsen, O., 1974: Incidence of proteolytic and some other bacterial populations in raw milk produced in South-Eastern Queensland. A total of 112 bulk raw milk samples from 12 local farm pickup runs and 16 country depots had the following mean counts/ml: standard plate count, 84 100; penicillin-resistant bacteria [method of Lightbody, DSA 27, 2212], 17 500; psychrotrophic bac...