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BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin

, : BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin. Journal of cell biology4 175(5): 693-701

Breast cancer-associated protein 1 (BRCA1) forms foci at sites of induced DNA damage, but any significance of these normal S-phase foci is unknown. BRCA1 distribution does not simply mirror or overlap that of replicating DNA; however, BRCA1 foci frequently abut sites of BrdU incorporation, mostly at mid-to-late S phase. Although BRCA1 does not overlap XIST RNA across the inactive X chromosome, BRCA1 foci position overwhelmingly in heterochromatic regions, particularly the nucleolar periphery where many centromeres reside. In humans and mice, including early embryonic cells, BRCA1 commonly associates with interphase centromere-kinetochore complexes, including pericentric heterochromatin. Proliferating cell nuclear antigen or BrdU labeling demonstrates that BRCA1 localizes adjacent to, or "paints," major satellite blocks as chromocenters replicate, where topoisomerase is also enriched. BRCA1 loss is often associated with proliferative defects, including postmitotic bridges enriched with satellite DNA. These findings implicate BRCA1 in replication-linked maintenance of centric/pericentric heterochromatin and suggest a novel means whereby BRCA1 loss may contribute to genomic instability and cancer.


PMID: 17145961

DOI: 10.2307/4152235

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Sazima, M.; Sazima, I., 1989: Oil-gathering bees visit flowers of eglandular morphs of the oil-producing Malpighiaceae. The behaviour of oil-gathering anthophorid bees visiting morphs of Banisteriopsis muricata and Heteropterys aceroides which lacked oil-producing calyx glands was observed in SE Brazil. Large and medium-sized species of Centris, and some Epicharis,...

Prasad, S.Mohan.; Kumar, D.; Zeeshan, M., 2005: Growth, photosynthesis, active oxygen species and antioxidants responses of paddy field cyanobacterium Plectonema boryanum to endosulfan stress. The Present paper deals with the insecticide endosulfan (5, 10 and 20 mu g/ml)-induced changes in physiological and biochemical parameters related to photosynthesis and defense systems in paddy field cyanobacterium Plectonema boryanum grown under...

Ichiko Tadatoshi; Kitagawa Toshihiro, 1988: China stone in Yifeng Jiangxi, China. Nendo Kagaku = Journal of the Clay Science Society of Japan 28(4): 205-211

Chiou Y Y.; Yang S S., 1979: Soil fungistasis of changhua area in taiwan. Chlamydospore suspensions of Fusarium oxysporum f. sp. lini, a pathogen of flax, were prepared and the percentage of chlamydospore germination was taken as an index of fungistasis. Some quantitative difference (P = 0.05 level significant) between...

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Chalmers J.P.; Draffan G.H.; Reid J.L.; Thorgeirsson S.S.; Davies D.S., 1971: Demethylation of 3 o methyl dopa in the rat. Life Sciences Part I Physiology & Pharmacology 10(21): 1243-1251

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