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BRCA1 ubiquitylation of CtIP: Just the tIP of the iceberg?

, : BRCA1 ubiquitylation of CtIP: Just the tIP of the iceberg?. Dna Repair 5(12): 1499-1504

Ubiquitylation is an important regulatory mechanism of many cellular processes. The breast and ovarian cancer-specific tumour suppressor BRCA1 is well acknowledged to be a RING/E3 ubiquitin ligase, however, identification of its physiological substrates has proved elusive. Recently published data have shown that the BRCA1-interacting protein CtIP is in fact ubiquitylated by BRCA1, and opens new avenues for the isolation of other substrate proteins.


PMID: 17027345

DOI: 10.1016/j.dnarep.2006.08.009

Other references

Mccarty, Mark, F., 2005: Up-regulation of PPAR-gamma coactivator-1 alpha as a strategy for preventing and reversing insulin resistance and obesity. Excessive accumulation of triglycerides and certain fatty acid derivatives in skeletal muscle and other tissues appears to mediate many of the adverse effects of insulin resistance syndrome. Although fatty diets and obesity can promote such accumu...

Rosen H.; Michel B.R., 1992: Neutrophil mediated inhibition of escherichia coli dna synthesis requires an intact myeloperoxidase system for optimal activity. Clinical Research 40(2): 351A

Mathew, A.C.; Singh, T.V.; Bosco, S.J.D., 2000: Coconut timber utilization. Indian Coconut Journal 31(3): 51-54

Wu, C.-Hsiu; Hsu, M.-Ming; Chang, Y.-Leong; Hsieh, F.-Jou, 1998: Vascular pathology of malignant cervical lymphadenopathy: Qualitative and quantitative assessment with power Doppler ultrasound. BACKGROUND. Malignant vascular pathology has traditionally been studied with invasive angiography or in vitro immunohistochemistry. The objective of this study was to investigate the vascular patterns and vascular density of benign and malignant c...

Okonofua, F.E.; Ayangade, S.O.; Ajibulu, O.A., 1988: Ultrasound measurement of fetal abdominal circumference and the ratio of biparietal diameter to transverse abdominal diameter in a mixed Nigerian population. The fetal abdominal circumference (FAC) and biparietal diameter to transverse abdominal diameter ratio (BPD/TAD) were measured by ultrasound in 219 normal pregnant Nigerian women from 20 weeks until term using the cross-sectional method. There was...

Juenemann, K.P.; A.S.ukri, S., 2000: Efficacy and tolerability of trospium chloride and tolterodine in 234 patients with urge-syndrome A double-blind, placebo-controlled, multicentre clinical trial. Neurourology & Urodynamics 19(4): 488-490

Comba, P.; Eisenschmidt, A.; Kipper, N.; Schießl, J., 2016: Glycosidase- and β-lactamase-like activity of dinuclear copper(II) patellamide complexes. Prochloron, a blue-green algae belonging to ancient prokaryotes, produces, like other cyanobacteria, cyclic pseudo-peptides, which are also found in its obligate symbiont ascidiae (Lissoclinum patellum). Although research has focused for some time...

Scherz, R.G., 1976: Restraint systems for the prevention of injury to children in automobile accidents. Highway accidents are the leading cause of child deaths in the United States from the ages of 1-14 years-6,122 such deaths occurred in 1973. In most instances deaths and permanent injuries occurred with the child as a passenger in an automobile. O...

Khananashvili, M.M., 1958: Interaction between the cortical parts of the visual and motor analysers after interruption of the association connexions in the neocortex. Fiziol Zhur Sssr [Transl] 44(9/10): 870-877

Wilson, C.; Levinson, A.P.tersen, R., 1990: An investigation into the status of Iris thompsonii (Iridaceae). Madrono: a west american journal of botany 37(2): 113-123