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BRCA1 ubiquitylation of CtIP: Just the tIP of the iceberg?


, : BRCA1 ubiquitylation of CtIP: Just the tIP of the iceberg?. Dna Repair 5(12): 1499-1504

Ubiquitylation is an important regulatory mechanism of many cellular processes. The breast and ovarian cancer-specific tumour suppressor BRCA1 is well acknowledged to be a RING/E3 ubiquitin ligase, however, identification of its physiological substrates has proved elusive. Recently published data have shown that the BRCA1-interacting protein CtIP is in fact ubiquitylated by BRCA1, and opens new avenues for the isolation of other substrate proteins.

US$19.90

PMID: 17027345

DOI: 10.1016/j.dnarep.2006.08.009


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