+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effects of electrical stimulation of the raphe area on the micturition reflex in cats

, : Effects of electrical stimulation of the raphe area on the micturition reflex in cats. Neuroscience 142(4): 1273-1280

The raphe nucleus has a variety of physiological functions, including emotion, regulation of skeletal muscle motoneurons, spinal transmission of nociceptive signals, sleep, respiration, gastric motility, and cardiovascular function. Recent evidence has shown that centrally administered serotonin has modulatory effects on micturition function, and that decreased brain serotonin might underlie depression and an overactive bladder. We applied high-frequency stimulation (HFS; 0.2-ms duration, 100 Hz) in the raphe nucleus and the adjacent midline area in 20 supracollicular decerebrate cats, which mostly elicited inhibition of the micturition reflex. The effective amplitude of the electrical stimulation for evoking inhibitory responses was less than 50 mu A. We also examined single neuronal activities in the raphe nucleus in response to isovolumetric spontaneous micturition reflexes. In total, 79 neurons were recorded in the raphe nucleus that were related to urinary storage/micturition cycles. Of the neurons recorded, the most common were tonic storage neurons (48%), followed by tonic micturition neurons (28%), phasic storage neurons (18%), and phasic micturition neurons (6%). In addition to the tonic/phasic as well as storage/micturition classification, the neurons showed diverse discharge patterns: augmenting, constant and decrementing, with the constant discharge pattern being most common. Among neurons in the raphe nucleus, the neurons with a decrementing discharge pattern were concentrated in the rostral portion, whereas the augmenting and constant neurons existed diffusely. The storage and micturition neurons were intermingled in the rostral portion, whereas they were separate in the caudal portion. In conclusion, the results of the present study indicate that HFS of the raphe area inhibits the micturition reflex and that there are micturition-related neuronal firings in the raphe area in cats, suggesting that the raphe nucleus is involved in neural control of micturition.


PMID: 16996219

DOI: 10.1016/j.neuroscience.2006.06.044

Other references

Kovács, J.K.; Horváth, Görgyi.; Kerényi, M.; Kocsis, Béla.; Emődy, L.; Schneider, Görgy., 2016: A modified bioautographic method for antibacterial component screening against anaerobic and microaerophilic bacteria. Direct bioautography is a useful method to identify antimicrobial compounds with potential therapeutic importance. Because of technical limitations till now, it has been applied only for aerobic bacteria. In this work we present the modification o...

Imbs, B.; Striukov, I.; Nazarenko, A.; Zydnev, N.; Zhukova, L.; Biriukova, A., 1974: Nutritive value of the feeds from the Stavropol Territory. Nauchnye trudy Stavropol'skii sel'skokhoziaistvennyi institut(37): 8-15

Bajuzikova, A., 1983: Schedule of classes - a current problem of health in the educational process. Zeitschrift für die Gesamte Hygiene und Ihre Grenzgebiete 29(7): 410-414

Quinn, J.B., 2002: Baby's bedding: is it creating toxic nerve gases?. Midwifery Today With International Midwife: 21-22

Nel, J., 1986: Note sur les Stenoptilia francais des saxifrages. Quatrieme contribution a la connaissance des premiers etats des Pterophoridae. (Lepidoptera Pterophoridae). The 2 species Stenoptilia pelidnodactyla and S. saxifraga, associated with Saxifraga granulata and Saxifraga continentalis respectively, were studied with reference to their immature stages in France. The Morphology and biotopes of the 5th stage o...

Laplantine, E.; Rossi, F.; Sahni, M.; Basilico, C.; Cobrinik, D., 2002: FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest. Unregulated FGF signaling affects endochondral ossification and long bone growth, causing several genetic forms of human dwarfism. One major mechanism by which FGFs regulate endochondral bone growth is through their inhibitory effect on chondrocyt...

Caballero, A.; Carazo, A.; Ortiz, M.; D.A.ustin, P., 1973: Placental transfer of fetal red blood corpuscles during pregnancy or delivery. Revue Francaise de Gynecologie et D'obstetrique 68(4): 261-278

Tay, B.A., 2014: Reduced dynamics of two oscillators collectively coupled to a thermal bath. We study the reduced dynamics of a pair of nondegenerate oscillators coupled collectively to a thermal bath. The model is related to the trilinear boson model where the idler mode is promoted to a field. Due to nonlinear coupling, the Markovian ma...

Gomez Alarcon, G.; Munoz, M.; Arino, X.; Ortega Calvo, J.J., 1995: Microbial communities in weathered sandstones: the case of Carrascosa del Campo church, Spain. An integrated study of the microorganisms growing on the weathered sandstone of the church of Carrascosa del Campo, Spain, was carried out. Whilst lichens played only a minor role in colonization, algae and bryophytes were abundant in the sandston...

Salamano, M.; Palchik, V.; Botta, C.; Colautti, M.; Perez, B.; Traverso, M.L., 2004: Asesoramiento al paciente en farmacias comunitarias. The objective of this work has been to know whether the information offered by community pharmacists is based on scientific evidence and whether the relationship benefit/risk of prescribed medication is adequately evaluated. For that matter, stude...