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Photochemistry of 2,6-diisopropylphenol (propofol)

, : Photochemistry of 2,6-diisopropylphenol (propofol). Photochemical & Photobiological Sciences 5(11): 1059-1067

The photochemistry of the anaesthetic agent propofol (PPF) was investigated in three different solvents of quite different polarity (cyclohexane, methanol and phosphate buffer pH 7) by means of nanosecond laser flash photolysis and absorption spectroscopy. GC-MS spectrometry measurements of PPF in cyclohexane have revealed the formation of two major products upon low intensity UV continuous irradiation of PPF in aerated solution: the diphenol derivative of PPF and 2,6-diisopropyl-p-benzoquinone (PPFQ). Only the diphenol compound was obtained in anaerobic solution. PPF phenoxyl radical (PPF ) generation has been assigned as the original step leading to the formation of both the diphenol compound and PPFQ in cyclohexane as revealed by laser flash photolysis at 266 nm and by electron paramagnetic resonance spectroscopy as well. Investigation of PPF by nanosecond flash photolysis at 266 nm in the other solvents revealed the occurrence of different photochemical processes depending on the nature and the polarity of the solvent. A reaction scheme is proposed in order to discuss the mechanism of reaction of PPF in all media.


PMID: 17077903

DOI: 10.1039/b605782a

Other references

Mohler, J.R., 1934: The Twelfth International Veterinary Congress. Science 80(2073): 271-272

Guaraldo, T.T.; Zanoni, T.B.; de Torresi, S.I.C.; Gonçales, V.R.; Zocolo, G.J.; Oliveira, D.P.; Zanoni, M.Valnice.B., 2013: On the application of nanostructured electrodes prepared by Ti/TiO2/WO3 "template": a case study of removing toxicity of indigo using visible irradiation. New assays with HepG2 cells indicate that Indigo Carmine (IC), a dye that is widely used as additive in many food and pharmaceutical industries exhibited cytotoxic effects. This work describes the development of a bicomponent nanostructured Ti/TiO...

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Olson, E.C., 1951: Diplocaulus. A study in growth and varation. Field Museum Publications Chicago Geological Series, 112: 55-154

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