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Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by diallyl disulfide (DADS)


, : Inhibition of angiogenic differentiation of human umbilical vein endothelial cells by diallyl disulfide (DADS). Life Sciences 80(6): 515-521

Angiogenesis is a crucial step in the growth and metastasis of cancers. The activation of endothelial cells and their further behaviour are very critical during angiogenesis. We analyzed the effect of diallyl disulfide (DADS) on angiogenesis in in vitro models using human umbilical vein endothelial cells (HUVECs). DADS significantly inhibited endothelial cell migration, invasion and tube formation. (3)H-thymidine proliferation assay clearly showed the inhibitory effect of DADS on the proliferation of HUVECs in vitro. The role of metalloproteinases has been shown to be important in angiogenesis; therefore, zymography was performed to determine whether DADS affected protease activity. Gelatin zymographic analysis showed the inhibitory effect of DADS on the activation of matrix metalloproteinases-MMP-2 and MMP-9. These findings suggest that DADS acts as an angiogenesis inhibitor by inhibiting the activation of matrix metalloproteinases during endothelial morphogenesis.

US$19.90

PMID: 17196623

DOI: 10.1016/j.lfs.2006.09.045


Other references

Markel K., 1970: The tooth skeleton of echinometra mathaei echinodermata echinoidea. Annotationes Zoologicae Japonenses 43(4): 188-199

Uchimiya, H.; Hirochika, H.; Hashimoto, H.; Hara, A.; Masuda, T.; Kasumimoto, T.; Harada, H.; Ikeda, J.E., 1986: Co-expression and inheritance of foreign genes in transformants obtained by direct DNA transformation of tobacco protoplasts. Nicotiana tabacum protoplasts were transformed with a plasmid containing an intact nopaline synthase gene and a chimaeric gene consisting of promoter and terminator regions from cauliflower mosaic virus and a structural gene for kanamycin resistan...

Lee, S.; Yang, K.; Yu, J.-eun, 2010: Epithermal Au-mineralization hosted in Cretaceous volcanic rocks from southwestern part of the Korean Peninsula; a preliminary study. Extensive epithermal systems hosted in Cretaceous volcanic rocks in the Sunshin gold mining area, southwestern part of the Korean Peninsula host two contrasting styles of mineralization (e.g., low and high sulfidation environment) in close proximi...

Roensen, K., 1975: Reducing sugars and crisp quality in potato cultivars in 1967-73. Comparative data are given on the content of reducing sugars in tubers of 57 potato cultivars grown in 1968-71. Responses of different cultivars to storage temperature were similar; low levels of reducing sugars were associated with pale-coloured...

Ruedemann, R.; Decker, C.E., 1934: The graptolites of the Viola Limestone. Thirty spp. and vars. from Oklahoma are descr. including: Desmograptus oklahomensis* (p.303), Dicranograptus nicholsoni geniculatus* (p.312), D. nicholsoni longibasalis* (p.313), and Climacograptus typicalis crassimarginalis* (p.322). A table show...

Wilhelm; Niskanen; Arenhövel, 1995: Photon absorption on a proton-proton pair in 3He. Physical Review. C, Nuclear Physics 51(5): 2841-2843

Anonymous, 2003: Vaccine news, March 2, 2000. Much is happening to accelerate development of vaccines, especially for AIDS, tuberculosis and malaria. Major initiatives were announced at a meeting of the President's Millennium Vaccine Initiative, March 2 at the White House.

D.F.anceschi, L.; Fessard, P.R.uyer; Jouault, H.; Brugnara, C.; Beuzard, Y., 1997: Therapy with either hydroxyurea or a combination of clotrimazole and magnesium prevents the in vivo dehydration induced by hypoxia in the SAD mouse. Blood 90(10 SUPPL 1 PART 1): 124A, Nov 15

Bartlett, De, 1979: Bluetongue: problems in diagnosis. Proceedings of annual meeting American Association of Veterinary Laboratory Diagnosticians: (22d) 205-213

Sorensen, B.; Kuhn, C.; Teuscher, F.; Schneider, F.; Weselake, R.; Wegner, J., 2006: Diacylglycerol acyltransferase (DGAT) activity in relation to muscle fat content and DGAT1 genotype in two different breeds of Bos taurus. The diacylglycerol acyltransferase (DGAT) activity in the longissimus dorsi (LD) and semitendinosus (ST) intramuscular fat and the effects of the DGAT1 genotype in Holstein-Friesian and Charolais bulls were studied to determine their influence on...