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An interesting issue of Diels-Alder selectivity discovered en route to 11-O-debenzoyltashironin


, : An interesting issue of Diels-Alder selectivity discovered en route to 11-O-debenzoyltashironin. Organic Letters 8(25): 5693-5695

The hypervalent iodine-mediated oxidative dearomatization/Diels-Alder cascade was examined in the context of the natural product 11-O-debenzoyltashironin. Interestingly, the regioselectivity of the Diels-Alder reaction can be completely switched by changing the dienophile. Trapping of allyl alcohols during the oxidative dearomatization gives rise to the five-membered acetal, while trapping of allenyl alcohols results in the six-membered acetal. [reaction: see text]

US$19.90

PMID: 17134249

DOI: 10.1021/ol062067i


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