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Cognitive dysfunction in beta-thalassemia minor


, : Cognitive dysfunction in beta-thalassemia minor. American Journal of Hematology 82(3): 203-207

beta-thalassemia minor is a common, hereditary, and mostly symptomless disease. Previous studies have shown that lower hemoglobin values are associated with poorer cognitive functions. We aimed to evaluate the cognitive function in patients with beta-thalassemia minor. Thirty-two male subjects with beta-thalassemia minor and 32 sex-, age-, and education statusmatched healthy subjects were enrolled in the study. Blood tests and P300 potentials were carried out. P300 potential latency in all patients was significantly longer than those in the control group (337.63 +/- 34.89 msec and 310.66 +/- 14.30 msec, respectively; t 4.046, P < 0.001). The amplitudes of P300 in patient group were significantly lower than those in the control group (5.19 +/- 3.59 mu V and 9.81 +/- 3.33 mu V, respectively; t 5.349, P < 0.001). In this study, we have found that P300 potentials are adversely affected for cognitive functions in patients with beta-thalassemia minor. Am. J. Hematol. 82:203-207, 2007. (c) 2006 Wiley-Liss, Inc.

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