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Critical role for NF-kappa B-induced JunB in VEGF regulation and tumor angiogenesis


, : Critical role for NF-kappa B-induced JunB in VEGF regulation and tumor angiogenesis. EMBO (European Molecular Biology Organization) Journal 26(3): 710-719

Regulation of vascular endothelial growth factor ( VEGF) expression is a complex process involving a plethora of transcriptional regulators. The AP-1 transcription factor is considered as facilitator of hypoxia-induced VEGF expression through interaction with hypoxia-inducible factor (HIF) which plays a major role in mediating the cellular hypoxia response. As yet, both the decisive AP-1 subunit leading to VEGF induction and the molecular mechanism by which this subunit is activated have not been deciphered. Here, we demonstrate that the AP-1 subunit junB is a target gene of hypoxia-induced signaling via NF-kappa B. Loss of JunB in various cell types results in severely impaired hypoxia-induced VEGF expression, although HIF is present and becomes stabilized. Thus, we identify JunB as a critical independent regulator of VEGF transcription and provide a mechanistic explanation for the inherent vascular phenotypes seen in JunB-deficient embryos, ex vivo allantois explants and in vitro differentiated embryoid bodies. In support of these findings, tumor angiogenesis was impaired in junB(-/-) teratocarcinomas because of severely impaired paracrine-acting VEGF and the subsequent inability to efficiently recruit host-derived vessels.

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Nakanishi, T.; Kadomatsu, K.; Okamoto, T.; Ichihara-Tanaka, K.; Kojima, T.; Saito, H.; Tomoda, Y.; Muramatsu, T., 1997: Expression of syndecan-1 and -3 during embryogenesis of the central nervous system in relation to binding with midkine. Midkine (MK) is a 13 kDa heparin-binding growth/differentiation factor, and its interaction with heparan sulfate proteoglycan is important in promotion of neurite outgrowth. This study was performed to reveal the species of syndecans that interact...

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Barba, E.L., 1965: Some criteria of the functional state of the liver in subjects with primary arterial hypotension. Most patients observed showed disorders of several functions of the liver. The cause of these disorders are latent inflammatory, processes in the liver and the biliary tracts. Liquidation or decrease of the inflammatory process led to the improvem...

Korn, S. v; Baulain, U.; Arnold, M.; Brade, W., 2005: Application of Magnetic Resonance Imaging and ultrasound to determine carcass quality in lamb. The constantly increasing requirements for carcass quality in lamb as well as the demand for a cost-efficient performance testing have also led to a discussion in Germany about the application of ultrasound to determine the carcass value. A total...

Robertson B., 1989: Surfactant deficiency and lung injury. Shapiro, D L And R H Notter (Ed ) Surfactant Replacement Therapy Ix+321p Alan R Liss, Inc : New York, New York, Usa Illus 127-144

Nordin, A.Siddiq.Amer.; Kadir, R.Abdul., 2015: Malaysia: empowering dentists into smoking cessation. Tobacco Control 23(4): 284-284

Ishihara, S.; Tsuchiya, S.; Horie, S.; Takayama, H.; Aimi, N.; Watanabe, K., 2000: Possible involvement of opioid kappa-receptor in the action of hirsutine on the central regulation of gastric acid secretion in rats. Japanese Journal of Pharmacology 82(Suppl 1): 59P

Reust, W.; Schwarz, A.; Aerny, J., 1984: Potato storage trial in a controlled atmosphere. Tubers of five table and industrial cultivars grown in Switzerland were stored in 2% O2 and 1, 6 or 12% CO2 at 8 degrees C and 85-90% RH. Bintje stored best under these conditions, although losses due to rot (principally Fusarium) were high, rangi...

Wilson, K.M.; Donovan, J.C.; Romano, J., 1953: An experiment in the teaching of obstetrics and gynecology at the graduate level; the application of clinical psychiatry in the teaching of obstetrics and gynecology. American Journal of Obstetrics and Gynecology 66(3): 654-662

Caldwell, M.L.; Doebbeling, S.E., 1935: A study of the concentration and properties of two amylases of barley malt. Two distinct amylases may be obtained from barley malt; each is destroyed by heat, gives positive protein color reactions, and shows the greatest saccharogenic activity at pH 4.3-4.6. Studies during the course of starch hydrolysis by the 2 enzymes...