+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Decreased heparin cofactor II activity is associated with impaired endothelial function determined by brachial ultrasonography and predicts cardiovascular events

, : Decreased heparin cofactor II activity is associated with impaired endothelial function determined by brachial ultrasonography and predicts cardiovascular events. International Journal of Cardiology 114(2): 152-158

Background: Heparin cofactor II (HCII) could inactivate thrombin after binding to dermatan sulfate at injured arterial walls, and has been shown to be a novel and independent antiatherosclerotic factor. However, the relation between plasma HCII activity and peripheral vascular endothelial function remains unclear.Methods: A total of 199 patients (mean age, 63 +/- 14 years) were enrolled and followed up for a median period of 24 months. Endothelial function was assessed using brachial ultrasonography to determine endothelium dependent flow-mediated vasodilation (FMD). Cox regression analyses were conducted for the 199 subjects, with cardiovascular events being defined as myocardial infarction (MI), percutaneous coronary intervention (PCI), coronary artery bypass grafting (CABG), ischemic stroke, and peripheral artery revascularization.Results: A total of 31 patients (16%) had cardiovascular events. Patients with cardiovascular events had significantly lower HCII activity (112 +/- 34 versus 127 +/- 34%, p = 0.027) and lower antithrombin III (ATIII) activity (82 +/- 12 versus 88 +/- 13%, p = 0.014) than those without events. By multivariate analysis, age (p = 0.012), hsCRP (p = 0.020) and HCII activity (p = 0.035) were correlated with FMD. Kaplan-Meier analysis was performed and showed plasma HCII (p = 0.036) and ATIII activities (p = 0.005) were predictors of cardiovascular events. By Cox regression analysis, plasma HCII activity (p = 0.026) could be an independent predictor of future cardiovascular events, but not ATIII.Conclusions: The present study demonstrates that plasma HCII activity is positively correlated with endothelial vasodilator function. Furthermore, plasma HCII activity could be a predictor of future cardiovascular events in patients with suspected coronary artery disease, suggesting its role in atherosclerosis.


PMID: 16650906

DOI: 10.1016/j.ijcard.2005.12.009

Other references

Mondal, B.Charan.; Mukherjee, T.; Mandal, L.; Evans, C.J.; Sinenko, S.A.; Martinez-Agosto, J.A.; Banerjee, U., 2012: Interaction between differentiating cell- and niche-derived signals in hematopoietic progenitor maintenance. Maintenance of a hematopoietic progenitor population requires extensive interaction with cells within a microenvironment or niche. In theDrosophilahematopoietic organ, niche-derived Hedgehog signaling maintains the progenitor population. Here, we...

Hofer, R., 1965: Intertrial proactive inhibition in short-term memory. Psychological Reports 17(3): 755-760

Koeniger, N.C.mielewski, M., 1986: A new approach to chemotherapy of varroatosis. European research on varroatosis control: proceedings of a meeting of the EC Experts' Group Bad Homburg 15-17 October 1986 edited by R Cavalloro: 236

Ragonese, A.E.; Covas, G., 1947: La flora halofila del sur de la Provincia de Santa Fe. An annotated list of 97 spp. in 26 families occupying saline soils in Santa Fe Province, Argentina. The climate of the region is described and the soils divided according to the vegetation covering them; thus on some soils Distichlis spicata was d...

Mayer, H.Michael.; Heider, F., 2016: "Slalom": Microsurgical Cross-Over Decompression for Multilevel Degenerative Lumbar Stenosis. Objective. Selective, bilateral multisegmental microsurgical decompression of lumbar spinal canal stenosis through separate, alternating cross-over approaches. Indications. Two-segmental and multisegmental degenerative central and lateral lumbar s...

Laudi, G., 1967: The ultrastructure of the chloro-plasts of leaflets of etiolated pea (Pisum sativum var. Alaska) plants, placed in the light to turn green, in the presence of indoleacetic acid. Previous observations indicated that the light-induced greening of apical leaves excised from etiolated pea seedlings was inhibited by IAA and that the effect was stronger when the leaves were taken from younger seedlings Further studies showed th...

Golden, H.E.; Boyer, E.W., 2008: Contemporary estimates of atmospheric nitrogen deposition to the watersheds of New York State, USA. Atmospheric inputs of reactive nitrogen (N) to ecosystems are a particular concern in the northeastern USA, including New York State, where rates of atmospheric N deposition are among the highest in the nation. We calculate the seasonal and annual...

Ali, S.Z.; Farmer, P.M.; Black, K.; Rosenthal, A., 1994: Masson's hemangioma of spinal meninges causing cord compression with paraplegia. Masson's hemangioma is a rare benign pathological entity. A unique case is reported of a 42 year old man with a spinal epidural mass who developed acute cord compression resulting in sudden onset of paraplegia. Histological examination of the...

Ravazzola, M.; Orci, L.; Girgis, S.I.; Galan Galan, F.; McIntyre, I., 1981: The lung is the major organ source of calcitonin in the lizard. Cell Biology International Reports 5(10): 937-944

Theorell, T.; Edhag, O.; Fagrell, B., 1978: Non-invasive methods for evaluating the importance of heart rate and atrial activity in cardiac pacing. Results of ballistocardiography and digital plethysmography studies in six patients with heart block. Ultralow frequency ballistocardiography (UFB) and digital pulse plethysmography (DPP) were performed in six patients with an external artificial pacemaker system. UFB was used mainly to evaluate the force of contraction of the left ventricle (IJ a...