geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Dibenzocyclooctadiene lignans: a class of novel inhibitors of multidrug resistance-associated protein 1


, : Dibenzocyclooctadiene lignans: a class of novel inhibitors of multidrug resistance-associated protein 1. Life Sciences 80(8): 741-748

We recently reported that dibenzocyclooctadiene lignans were a novel class of P-glycoprotein (P-gp) inhibitors. In this study, we demonstrated that the lignans of this class were also effective inhibitors of multidrug resistance-associated protein 1 (MRP1). The activities of 5 dibenzocyclooctadiene lignans (schisandrin A, schisandrin B, schisantherin A, schisandrol A, and schisandrol B) to reverse MRP1-mediated drug resistance were tested using HL60/Adriamycin (ADR) and HL60/Multidrug resistance-associated protein (MRP), two human promyelocytic leukemia cell lines with overexpression of MRP1 but not P-gp. The five lignans could effectively reverse drug resistance of the two cell lines to vincristine, daunorubicin, and VP-16. This study, together with our previous reports, proves that dibenzocyclooctadiene lignans have multiple activities against cancer multidrug resistance, including inhibition of P-gp and MRP1, and enhancement of apoptosis. Considering that cancer multidrug resistance (MDR) is multifactorial, agents with broad activities are preferable to the use of combination of several specific modulators to prevent drug-drug interaction and cumulative toxicity.

US$19.90

PMID: 17129588

DOI: 10.1016/j.lfs.2006.11.002


Other references

Schwarzenberg, H.; Müller-Hülsbeck, S.; Glüer, C.C.; Steffens, J.C.; Heller, M., 1998: Evaluation of maximum neointima proliferation and plaque morphology in iliac self-expanding nitinol stents with intravascular sonography. The purpose of this study was to use intravascular sonography to evaluate neointima formation, plaque location, and the performance of self-expanding nitinol (Memotherm) stents in iliac arteries. Seventeen patients (mean age, 64+/-9.4 years) with...

Kimura, T.; Xu, Y.; Komiyama, M., 2010: Human telomeric RNA r(UAGGGU) sequence forms parallel tetraplex structure with U-quartet. Recent studies showed that telomere DNAs are transcribed into telomeric-repeat-containing RNAs in mammalian cells and these RNAs are associated with the chromosome ends. Therefore, they may be key components of telomere machinery. We have reported...

Geldermann H.; Schmid D.O.; Gruhn R.; Haring F., 1971: On the distribution of serum transferrins and blood groups in sheep suffering from microphthalmia. Zuechtungskunde 43(5): 319-323

Mamaev, YuL.; Parukhin, AM., 1975: New monogeneans of the subfamily Diclidophorinae (Monogeiidea, Diclidophoridae). Trudy Biol-pochvenn Inst Vladivostok, 26129: 126-142

Chaitanya, C.V.; Koirala, N.; Mideksa, K.G.; Anwar, A.R.; Schmidt, G.; Deuschl, G.; Groppa, S.; Muthuraman, M., 2016: Testing the effects of pre-processing on voxel based morphometry analysis. Voxel based morphometry (VBM) is an automated analysis technique which allows voxel-wise comparison of mainly grey-matter volumes between two magnetic resonance images (MRI). Two main analysis processes in VBM are possible. One is cross-sectional...

Cohen Hattab, K.; Kerber, J., 2004: Literature, cultural identity and the limits of authenticity: a composite approach. Although tourism scholarship has paid much attention to the concept of authenticity in relation to the homogenization of tourism representation, this term has limits that curb its usefulness for analysing subtle interrelations of place, representa...

Ridsdale, L., 1990: Use and abuse of placebos. Practitioner 234(1497): 1028, 1031-1028, 1031

Dimbiloglu M.E.; Appert H.E.; Howard J.M.; Pairent F.W., 1968: The relative tolerance of the dog to intra venous infusions of pancreatic juice enz amylase enz lipase enz trypsin. Surgery (St Louis) 64(4): 805-813

Kim, D.H.; Park, J.C., 2007: Completion sleeve pneumonectomy for suture line recurrence of lung cancer after sleeve lobectomy. The most appropriate treatment for suture line recurrence of lung cancer after bronchial sleeve lobectomy is completion pneumonectomy. While completion pneumonectomy may not be justified from an oncological point of view due to the positive bronch...

Meng, Q.; Guo, H.; Xiao, L.; Cui, Y.; Guo, R.; Xiao, D.; Huang, Y., 2014: mTOR regulates TGF-β₂-induced epithelial-mesenchymal transition in cultured human lens epithelial cells. Post-cataract surgery fibrosis in the lens capsule is caused by epithelial to mesenchymal transition (EMT) of the lens epithelium. Mammalian target of rapamycin (mTOR) has been demonstrated to be a key regulator of EMT. The aim of this study was t...