+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia

, : Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia. American Journal of Human Genetics 80(1): 12-18

The chitinase 3-like 1 gene (CHI3L1) is abnormally expressed in the hippocampus of subjects with schizophrenia and may be involved in the cellular response to various environmental events that are reported to increase the risk of schizophrenia. Here, we provide evidence that the functional variants at the CHI3L1 locus influence the genetic risk of schizophrenia. First, using case-control and transmission/disequilibrium-test (TDT) methodologies, we detected a significant association between schizophrenia and haplotypes within the promoter region of CHI3L1 in two independent cohorts of Chinese individuals. Second, the at-risk CCC haplotype (P = .00058 and .0018 in case-control and TDT studies, P = .00058 respectively) revealed lower transcriptional activity (P = 2.2 x 10(-7)) and was associated with lower expression (P = 3.1 x 10(-s)) compared with neutral and protective haplotypes. Third, we found that an allele of SNP4 (rs4950928), the tagging SNP of CCC, impaired the MYC/MAX-regulated transcriptional activation of CHI3L1 by altering the transcriptional-factor consensus sequences, and this may be responsible for the decreased expression of the CCC haplotype. In contrast, the protective TTG haplotype was associated with a high level of CHI3L1 expression. Our findings identify CHI3L1 as a potential schizophrenia-susceptibility gene and suggest that the genes involved in the biological response to adverse environmental conditions are likely to play roles in the predisposition to schizophrenia.


PMID: 17160890

DOI: 10.1086/510438

Other references

Dugernier, T.; Starkel, P.; Laterre, P.F.; Reynaert, M.S., 1996: Severe acute pancreatitis: pathophysiologic mechanisms underlying pancreatic necrosis and remote organ damage. Despite advances in surgical and intensive care the mortality of severe acute pancreatitis still ranges between 10 and 20%. Fundamentally, the severity of acute pancreatitis, both in term of propensity and intensity of locoregional and remote comp...

Tasaki, K.; Maskarinec, G.; Shumay, D.M.; Tatsumura, Y.; Kakai, H., 2002: Communication between physicians and cancer patients about complementary and alternative medicine: exploring patients' perspectives. The aim of this paper is to identify barriers to communication between physicians and cancer patients regarding complementary and alternative medicine (CAM) by exploring the perspectives of patients. In face of the recent popularity of CAM use amo...

Michael F.H.chella Jr.; Gordon E.B.own Jr., 1984: Structure and viscosity of rhyolitic composition melts. The average local structure of a rhyolitic composition glass has been determined at 25°C using X-ray radial distribution analysis (RDA) and quasi-crystalline modelling and is best described as similar to that in a stuffed framework composed princ...

Peels, H. von., 1907: N m, eine neue Gattung und Art der Blastoidea. St Peterburg Travaux de la Societe des Naturalistes, 35(Fasc. 5: 15-20

Conejero, R.; Lorenzo, A.; Arnal, F.; Garcia, J., 1987: Significance of the changes in plasma amino-acid levels in meningococcal infection. A series of patients with meningococcal infections have been studied and divided in two groups: Group I patients with meningococcal sepsis and group II, those with meningococcal meningitis. Patients in group I presented with more severe encephalop...

Carter, R.M., 1983: Finishing eastern hardwoods. A well-illustrated guide to hardwood finishing processes and equipment in the eastern USA.

Mata A.J.; Acuna J., 1987: Study of petroleum contamination on the caribbean coast of costa rica 1981 1985. Caribbean Journal of Science 23(1): 41-50

Peschel, N.; Helfrich-Förster, C., 2011: Setting the clock--by nature: circadian rhythm in the fruitfly Drosophila melanogaster. Nowadays humans mainly rely on external, unnatural clocks such as of cell phones and alarm clocks--driven by circuit boards and electricity. Nevertheless, our body is under the control of another timer firmly anchored in our genes. This evolutiona...

Salter, Russell D., 1994: Intracellular transport of class I HLA molecules is affected by polymorphic residues in the binding groove. Intracellular transport of class I MHC complexes is dependent on assembly of class I heavy chains with beta 2-microglobulin (beta 2m) and peptides. This suggests that amino acid residues of individual class I molecules which are important for thei...

Potel, C.; Rey, S.; Otero, S.; Rubio, J.; Álvarez, M., 2016: Molecular characterization and clonal diversity of meticillin-resistant Staphylococcus aureus isolated from the community in Spain: emergence of clone sequence type 72. Sequence type 72 meticillin-resistant Staphylococcus aureus (ST72 MRSA) was recently detected in our hospital. Although in Europe this clone is rarely isolated, it is the leading cause of community-associated MRSA infections in Korea, spreading al...