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Granulocyte, monocyte/macrophage apheresis for inflammatory bowel disease: the first 100 patients treated in Scandinavia

, : Granulocyte, monocyte/macrophage apheresis for inflammatory bowel disease: the first 100 patients treated in Scandinavia. Scandinavian Journal of Gastroenterology 42(2): 221-227

Objective. Selective leukocyte apheresis is a new type of non-pharmacological treatment for patients with active ulcerative colitis and Crohn's disease. Preliminary data have indicated that this type of therapy is safe and efficacious, and large sham-controlled studies are currently in progress. In Scandinavia, a substantial number of patients with chronic inflammatory bowel disease have already received leukocyte apheresis on a compassionate use basis and the aim of this study was to report the clinical outcome and adverse events in the first patients treated. Material and methods. Clinical details of the first consecutive 100 patients with inflammatory bowel disease treated with granulocyte, mono cyte/macrophage (Adacolumn) apheresis in Scandinavia were prospectively registered. Median length of follow-up was 17 months, (range 5-30). Results. The study population comprised 52 patients with ulcerative colitis, 44 patients with Crohn's disease and 4 patients with indeterminate colitis. In 97 patients the indication for Adacolumn treatment was steroid-refractory or steroid-dependent disease. Clinical remission was attained in 48% of the patients with ulcerative colitis, and an additional 27% had a clinical response to the apheresis treatment. The corresponding figures for patients with Crohn's disease were 41% and 23%, respectively. Complete steroid withdrawal was achieved in 27 out of the 50 patients taking corticosteroids at baseline. Adverse events were reported in 15 patients and headache was most frequently reported (n=7). Conclusions. Granulocyte, mono cyte/macrophage apheresis treatment seems to be a valuable adjuvant therapy in selected patients with refractory inflammatory bowel disease. The risk for toxicity or severe adverse events appears to be low.


PMID: 17327942

DOI: 10.1080/00365520600979369

Other references

El-Mallakh, P., 2007: Doing my best: poverty and self-care among individuals with schizophrenia and diabetes mellitus. Diabetes mellitus (DM) is more common among individuals with schizophrenia/schizoaffective disorders than among the general population. Eleven mental health consumers diagnosed with comorbid schizophrenia/schizoaffective disorder and DM participat...

Bartell, P.F.; Orr, T.E.; Chudio, B., 1970: Purification and Chemical Composition of the Protective Slime Antigen of Pseudomonas aeruginosa. The slime obtained from Pseudomonas aeruginosa strain BI was purified by a system of ethanol precipitation, gel filtration, and ion-exchange chromatography. The slime polysaccharide was eluted as a single peak at a potassium chloride molarity of 0...

Huggert, L.; Ulefors, S-O., 1971: Anteckningar om svenska Coleoptera. Ent Tidskr, 92: 54-65,In Swedish

Mohammed, A.P.; Dhunputh, P.; Chiluka, R.; Umakanth, S., 2016: An unusual case of invasive aspergillosis in an immunocompetent individual. Invasive aspergillosis is a highly lethal opportunistic infection that poses a significant threat to immunocompromised patients. With studies suggesting that the incidence of this disease is increasing, and mortality rates remain high, early diagn...

Fuller, D.; Davis, T.; Buckner, R.; Patel, S., 1997: Rapid, direct identification of group B Streptococcus during pregnancy. Abstracts of the Interscience Conference on Antimicrobial Agents & Chemotherapy 37: 95

Herrmann, H-J., 1991: Untersuchungen an der Batrachofauna von Vasilievskoe bei Moskau. Veroeffentlichungen Naturhistorisches Museum Schloss Bertholdsburg Schleusingen, 6: 25-29

Mishima, H.; Hirata, H.; Ono, H.; Choshi, K.; Nishi, Y.; Fukuda, K., 1985: A Fukuyama type of congenital muscular dystrophy associated with atypical gyrate atrophy of the choroid and retina. A case report. A three-year-ten-month old boy with the Fukuyama type of congenital muscular dystrophy (FCMD), early onset of muscular hypotonia, severe mental retardation, a slow progressive course and a characteristic fundus appearance similar to that of gyrate...

Osuide, S.O., 1988: The 1988 Nigerian population policy. The population of Nigeria is one of the fastest growing rates in the world at 2.5-3.5%/ year. The estimated population was 101.11 million in 1987 and by 2015 is projected to be 280 million. Nigeria was the 10th most populous country in 1985 and by...

LeFever Julie A., 1992: Horizontal drilling in the Williston Basin, United States and Canada. Pages 177-197 1992

Li, J.; Liu, J.; Peng, H-Qing., 2008: Ethyl 4-nitro-phenyl-acetate. In the asymmetric unit of the title compound, C(10)H(11)NO(4), there are two crystallographically independent mol-ecules, which are connected via a C-H⋯O hydrogen bond. The crystal structure is stabilized by this hydrogen bond together with an N...