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Histoenzymic observations on the kidneys of rabbits due to-cypermethrin toxicity


, : Histoenzymic observations on the kidneys of rabbits due to-cypermethrin toxicity. Indian Journal of Animal Sciences 77(2): 148-150

The cypermethrin was administered orally to 6 healthy rabbits of either sex @ 0.25 mg/kg body weight daily for 3 0 days to elucidate the alterations in the histoenzymic pattern of oxidoreductases in the kidneys. After completion of the experimental periods, both the kidneys were collected immediately after slaughtering the rabbits. The cryostat sections of 10 pm thickness were obtained at-20 degrees C and incubated to demonstrate various oxido-reductases. A weak to moderate activity of SDH, LDH and G-6-PD was observed in the proximal and distal convoluted tubules. The activity of SDH was negligible, whereas the LDH and G-6-PD was weak in the glomeruli and loop of Henle. The activity of NADH and NADPH-D was moderate to strong in renal tubules and weak in the glomeruli. The alterations in the distribution pattern of oxidoreductases in the rabbit kidney reflects the general loss of enzymic activity which leads to impair the physiological activity of the organ due to cypermethrin toxicity.

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